INT201155

Context Info Confidence 0.37 First Reported 2007 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.13 Pain Relevance 0.05

plasma membrane (Jph2)

Anatomy Link Frequency heart 1 reticulum 1 Jph2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Calcium channel 5 100.00 imagery 9 5.00 sodium channel 7 5.00 Action potential 5 5.00 potassium channel 3 5.00 beta blocker 3 5.00 fibrosis 2 5.00 addiction 2 5.00 ketamine 1 5.00 Catecholamine 1 5.00

Disease Link Frequency Relevance Heat Hypertrophic Cardiomyopathy 41 99.04 Myocardial Infarction 33 97.36 Hypertrophy 81 79.44 Glycogen Storage Disease 1 74.88 Coronary Heart Disease 4 74.32 Disease 17 33.68 Left Ventricular Hypertrophy 2 29.52 Malignant Neoplastic Disease 3 5.72 Syndrome 37 5.00 Heart Arrhythmia 17 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Therefore, the upstream pathways that regulate JP-2 may become putative candidates for therapeutic targeting against heart failure.

Regulation (regulate) of JP-2 in heart associated with myocardial infarction

1) Confidence 0.37 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1764437 Disease Relevance 0.39 Pain Relevance 0

This is the first time that JPH2, which is thought to play a role in approximating the sarcoplasmic reticulum calcium release channels and plasmalemmal L-type calcium channels, has been implicated in the pathogenesis of HCM [33].

Regulation (implicated) of JPH2 in reticulum associated with hypertrophic cardiomyopathy and calcium channel

2) Confidence 0.03 Published 2008 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2363724 Disease Relevance 0.74 Pain Relevance 0.05

General Comments

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