INT201155

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.13
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Jph2)
Anatomy Link Frequency
heart 1
reticulum 1
Jph2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcium channel 5 100.00 Very High Very High Very High
imagery 9 5.00 Very Low Very Low Very Low
sodium channel 7 5.00 Very Low Very Low Very Low
Action potential 5 5.00 Very Low Very Low Very Low
potassium channel 3 5.00 Very Low Very Low Very Low
beta blocker 3 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Catecholamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophic Cardiomyopathy 41 99.04 Very High Very High Very High
Myocardial Infarction 33 97.36 Very High Very High Very High
Hypertrophy 81 79.44 Quite High
Glycogen Storage Disease 1 74.88 Quite High
Coronary Heart Disease 4 74.32 Quite High
Disease 17 33.68 Quite Low
Left Ventricular Hypertrophy 2 29.52 Quite Low
Malignant Neoplastic Disease 3 5.72 Low Low
Syndrome 37 5.00 Very Low Very Low Very Low
Heart Arrhythmia 17 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, the upstream pathways that regulate JP-2 may become putative candidates for therapeutic targeting against heart failure.


Regulation (regulate) of JP-2 in heart associated with myocardial infarction
1) Confidence 0.37 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1764437 Disease Relevance 0.39 Pain Relevance 0
This is the first time that JPH2, which is thought to play a role in approximating the sarcoplasmic reticulum calcium release channels and plasmalemmal L-type calcium channels, has been implicated in the pathogenesis of HCM [33].
Regulation (implicated) of JPH2 in reticulum associated with hypertrophic cardiomyopathy and calcium channel
2) Confidence 0.03 Published 2008 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2363724 Disease Relevance 0.74 Pain Relevance 0.05

General Comments

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