INT201159

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.16
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (Ryr2)
Anatomy Link Frequency
margin 1
Ryr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ketamine 1 22.56 Low Low
addiction 18 5.00 Very Low Very Low Very Low
imagery 13 5.00 Very Low Very Low Very Low
tetrodotoxin 6 5.00 Very Low Very Low Very Low
Action potential 4 5.00 Very Low Very Low Very Low
Calcium channel 2 5.00 Very Low Very Low Very Low
Nerve growth factor 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 80 98.24 Very High Very High Very High
Myocardial Infarction 27 46.96 Quite Low
Cv Unclassified Under Development 5 43.84 Quite Low
Body Weight 1 35.84 Quite Low
Ganglion Cysts 14 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 3 5.00 Very Low Very Low Very Low
Coronary Heart Disease 3 5.00 Very Low Very Low Very Low
Infection 3 5.00 Very Low Very Low Very Low
Hypertension 2 5.00 Very Low Very Low Very Low
Fibrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In testing the principle that a stability margin must be broached for cellular uncoupling to occur, we found that decreasing LCC-RyR coupling efficiency by a factor other than hypertrophy obeyed the same principle.
Negative_regulation (decreasing) of RyR in margin associated with hypertrophy
1) Confidence 0.36 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1764437 Disease Relevance 0.16 Pain Relevance 0
First, involvement of bulk [Ca2+] increases generated by locally triggered RyRs were excluded because preventing RyR activity did not affect signal strength (Fig.
Negative_regulation (preventing) of RyR
2) Confidence 0.09 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2592819 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

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