INT201163

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Context Info
Confidence 0.08
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 2.97
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (Atp2a2)
Anatomy Link Frequency
heart 3
cardiomyocytes 1
Atp2a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
imagery 27 62.08 Quite High
Action potential 3 46.48 Quite Low
ischemia 6 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
Calcium channel 6 5.00 Very Low Very Low Very Low
tetrodotoxin 3 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 156 99.60 Very High Very High Very High
Myocardial Infarction 93 97.94 Very High Very High Very High
Hypertrophy 240 92.68 High High
Apoptosis 75 92.32 High High
Injury 48 59.72 Quite High
Lymphatic System Cancer 3 36.68 Quite Low
B-cell Acute Lymphoblastic Leukemia 3 36.32 Quite Low
Hypertension 6 30.20 Quite Low
Cv Unclassified Under Development 21 5.00 Very Low Very Low Very Low
Stress 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In many heart failure models, decreased SR Ca2+ load [33,34] due to reduced expression of SERCA protein [11,33] or impaired SERCA regulation by phospholamban [35,36] are responsible, at least in part, for the E-C uncoupling.
Regulation (regulation) of SERCA in heart associated with myocardial infarction
1) Confidence 0.08 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1764437 Disease Relevance 0.55 Pain Relevance 0.03
Many studies have shown that SERCA activity is down-regulated, and Na/Ca exchange up-regulated, in failing heart cells, both preventing the SR from filling [8,11].
Regulation (regulated) of SERCA in heart
2) Confidence 0.07 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1764437 Disease Relevance 0.29 Pain Relevance 0
Many studies have shown that SERCA activity is down-regulated, and Na/Ca exchange up-regulated, in failing heart cells, both preventing the SR from filling [8,11].
Regulation (regulated) of SERCA in heart
3) Confidence 0.07 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1764437 Disease Relevance 0.29 Pain Relevance 0
Furthermore, thiopental attenuated alterations of genes involving Ca2+ regulation and significantly modulated abnormal changes of NCX and SERCA2a genes in hypoxia-reoxygenated neonatal cardiomyocytes.
Regulation (changes) of SERCA2a in cardiomyocytes associated with hypoxia
4) Confidence 0.01 Published 2010 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2824862 Disease Relevance 0.61 Pain Relevance 0
To confirm functional changes of SERCA2a and NCX, Western blot analyses with anti-SERCA2a and anti-NCX antibodies were performed.
Regulation (changes) of SERCA2a
5) Confidence 0.01 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.56 Pain Relevance 0
Treatment of hypoxia-reoxygenated cells with 50 ┬ÁM thiopental resulted in up-regulation of mRNA transcription levels of SERCA2a and PMCA1 (p < 0.05), and decreased NCX gene expression (p < 0.01).
Regulation (regulation) of SERCA2a associated with hypoxia
6) Confidence 0.01 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.66 Pain Relevance 0

General Comments

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