INT20121

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Context Info
Confidence 0.54
First Reported 1986
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 34
Total Number 34
Disease Relevance 15.50
Pain Relevance 4.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CYBB) oxidoreductase activity (CYBB) plasma membrane (CYBB)
cytoplasm (CYBB)
Anatomy Link Frequency
neutrophils 3
granulocytes 2
blood 1
neuronal 1
HSCs 1
CYBB (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 60 99.84 Very High Very High Very High
addiction 32 99.28 Very High Very High Very High
Adalimumab 73 97.92 Very High Very High Very High
qutenza 17 97.12 Very High Very High Very High
antagonist 17 96.64 Very High Very High Very High
chemokine 16 95.96 Very High Very High Very High
Paracetamol 6 95.60 Very High Very High Very High
aspirin 4 95.60 Very High Very High Very High
Restless leg syndrome 1 95.52 Very High Very High Very High
Morphine 4 95.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Parasitic Infection 1 99.92 Very High Very High Very High
Neutrophil Disorders 28 99.88 Very High Very High Very High
Cirrhosis 93 99.82 Very High Very High Very High
INFLAMMATION 484 99.64 Very High Very High Very High
Disease 252 99.60 Very High Very High Very High
Primary Sclerosing Cholangitis 1 99.08 Very High Very High Very High
Injury 160 98.92 Very High Very High Very High
Death 135 98.74 Very High Very High Very High
Urological Neuroanatomy 117 98.16 Very High Very High Very High
Bacterial Infection 2 98.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tobramycin sulfate and the triple combination of penicillin G sodium-metronidazole hydrochloride-tobramycin sulfate significantly reduced the NADPH oxidase activity at all dosages studied.
Negative_regulation (reduced) of NADPH oxidase
1) Confidence 0.54 Published 1986 Journal Arch Surg Section Abstract Doc Link 3942501 Disease Relevance 0 Pain Relevance 0.18
[Studies on relationships between the inhibition of human neutrophil NADPH oxidase by anti-inflammatory drugs and development of bacterial infections].
Negative_regulation (inhibition) of NADPH oxidase in neutrophil associated with inflammation, cinod and bacterial infection
2) Confidence 0.52 Published 1990 Journal Kansensh?gaku Zasshi Section Title Doc Link 2243189 Disease Relevance 0.29 Pain Relevance 0.30
activation of apocynin is a prerequisite for inhibition of NADPH-oxidase and
Negative_regulation (inhibition) of NADPH-oxidase
3) Confidence 0.51 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.59 Pain Relevance 0.08
In the original report of apocynin, as an NADPH-oxidase inhibitor, it
Negative_regulation (inhibitor) of NADPH-oxidase
4) Confidence 0.51 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.46 Pain Relevance 0
efficacious and selective inhibitors of vascular NADPH-oxidase as potential
Negative_regulation (inhibitors) of NADPH-oxidase
5) Confidence 0.51 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.84 Pain Relevance 0.03
Apocynin has been used as an efficient inhibitor of the complex NADPH-oxidase
Negative_regulation (inhibitor) of NADPH-oxidase
6) Confidence 0.51 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.14 Pain Relevance 0
Apocynin: Molecular Aptitudes

Apocynin is a naturally occurring methoxy-substituted catechol, experimentally used as an inhibitor of NADPH-oxidase.

Negative_regulation (inhibitor) of NADPH-oxidase
7) Confidence 0.51 Published 2008 Journal Mediators of Inflammation Section Title Doc Link PMC2593395 Disease Relevance 0.45 Pain Relevance 0.15
We conclude that NADPH oxidase activity can be adversely affected by the circulating levels of common antibiotics and sedatives.
Negative_regulation (affected) of NADPH oxidase
8) Confidence 0.40 Published 1986 Journal Arch Surg Section Abstract Doc Link 3942501 Disease Relevance 0 Pain Relevance 0.16
inhibit NADPH-oxidase: for instance, it inhibits cytochrome P450 activity in
Negative_regulation (inhibit) of NADPH-oxidase
9) Confidence 0.37 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.06 Pain Relevance 0
The property of apocynin as an inhibitor of NADPH-oxidase and
Negative_regulation (inhibitor) of NADPH-oxidase
10) Confidence 0.37 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.46 Pain Relevance 0.15
effect of NADPH-oxidase inhibition and, to a lesser extent in less extension,
Negative_regulation (inhibition) of NADPH-oxidase
11) Confidence 0.37 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.33 Pain Relevance 0.04
However, HMDM from patients with CGD that were shown to lack active NADPH-oxidase, but
Negative_regulation (lack) of NADPH-oxidase associated with disease
12) Confidence 0.37 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.67 Pain Relevance 0
collared arteries by suppressing the NADPH-oxidase activity rather than
Negative_regulation (suppressing) of NADPH-oxidase
13) Confidence 0.37 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.51 Pain Relevance 0.03
future treatments should also focus on NADPH-oxidase inhibition as an effective
Negative_regulation (inhibition) of NADPH-oxidase
14) Confidence 0.37 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.88 Pain Relevance 0
decreased NADPH-oxidase activity and reduced the superoxide level, in addition
Negative_regulation (decreased) of NADPH-oxidase
15) Confidence 0.37 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 1.31 Pain Relevance 0.36
More evidence involving NADPH oxidase activation in the restriction of SOCE in fMLF-activated neutrophils is derived from experiments using a selective inhibitor of NADPH oxidase, diphenyleneiodonium.
Negative_regulation (inhibitor) of NADPH oxidase in neutrophils
16) Confidence 0.37 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0.22 Pain Relevance 0
Blockade of Ca2+ influx is accompanied by a slowed phagocytosis and a decrease of NADPH oxidase activity.
Negative_regulation (decrease) of NADPH oxidase
17) Confidence 0.37 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
Later, effects of fMLF on SOCE were investigated in neutrophil granulocytes of patients suffering from chronic granulomatous disease, who possess a deficient NADPH oxidase activity and an attenuation of depolarization following fMLF stimulation.
Negative_regulation (deficient) of NADPH oxidase in granulocytes associated with neutrophil disorders
18) Confidence 0.37 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0.23 Pain Relevance 0
LPS-induced neuronal death was significantly inhibited by diphenylene iodonium (DPI), an inhibitor of NADPH oxidase.
Negative_regulation (inhibitor) of NADPH oxidase in neuronal associated with death
19) Confidence 0.35 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17855475 Disease Relevance 0.76 Pain Relevance 0.17
In disagreement with the fact, largely reported, that PMA stimulates NADPH oxidase independently of Ca2+ influx, some studies demonstrate that PMA-activated NADPH oxidase is decreased significantly in the absence of extracellular Ca2+ [129].
Negative_regulation (decreased) of NADPH oxidase
20) Confidence 0.28 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0.05 Pain Relevance 0.03

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