INT201239

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Context Info
Confidence 0.51
First Reported 2006
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.07
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (FOXM1) nucleus (FOXM1) embryo development (FOXM1)
cell cycle (FOXM1) DNA binding (FOXM1) transcription factor binding (FOXM1)
Anatomy Link Frequency
posterior 1
FOXM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 3 89.16 High High
Pain 14 72.92 Quite High
insula 50 59.08 Quite High
imagery 52 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
iatrogenic 1 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lung Cancer 69 100.00 Very High Very High Very High
Adhesions 11 99.56 Very High Very High Very High
Metastasis 57 96.08 Very High Very High Very High
Disease 28 95.84 Very High Very High Very High
Malignant Neoplastic Disease 17 92.40 High High
Skin Cancer 70 91.88 High High
Apoptosis 1 89.36 High High
Lymphadenopathy 6 85.68 High High
Cancer 78 80.68 Quite High
Pressure And Volume Under Development 2 76.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The differentially expressed genes include metabolic enzymes, transcription factors such as Forkhead Box M1 (FoxM1) and cell adhesion molecules such as Osteopontin (SPP1).


Gene_expression (expressed) of FoxM1 associated with adhesions
1) Confidence 0.51 Published 2007 Journal BMC Cancer Section Abstract Doc Link PMC1865555 Disease Relevance 0.72 Pain Relevance 0
Prognosis of MPM is dismal and there is no standard treatment approach: although multimodality treatment including intraperitoneal chemotherapy and cytoreductive surgery may result in prolonged survival in selected patients [5], either best supportive care or systemic chemotherapy with palliative intent are accepted approaches.
Gene_expression (Prognosis) of MPM associated with lung cancer and palliative
2) Confidence 0.24 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1764904 Disease Relevance 1.43 Pain Relevance 0.16
Furthermore, contributions of the FOX gene family, in particular FOXM1 and FOXE1, appear to be involved in downstream signalling [35–38].
Gene_expression (contributions) of FOXM1
3) Confidence 0.14 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC3021865 Disease Relevance 0.83 Pain Relevance 0
As recently as 2003, single-agent chemotherapy regimens produced response rates below 20% in MPM (Pistolesi and Rusthoven 2004), and single agents had not been shown to improve median survival.
Gene_expression (produced) of MPM associated with lung cancer
4) Confidence 0.11 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503655 Disease Relevance 1.02 Pain Relevance 0
During the fourth phase participants were either presented with paired visual and auditory stimuli (CS- and UCS, n = 32) as in the preceding phase, visual stimuli in isolation (CS+, n = 32), or randomly interspersed null events (n = 32).
Gene_expression (presented) of phase
5) Confidence 0.05 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1800857 Disease Relevance 0 Pain Relevance 0
Based on the results of the global ANOVA we performed a separate (4 × 2) ANOVAs with factors phase × hemisphere for each ROI.
Gene_expression (hemisphere) of phase
6) Confidence 0.05 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1800857 Disease Relevance 0 Pain Relevance 0.03
During the fourth phase participants were either presented with paired visual and auditory stimuli (CS- and UCS, n = 32) as in the preceding phase, visual stimuli in isolation (CS+, n = 32), or randomly interspersed null events (n = 32).
Gene_expression (presented) of phase
7) Confidence 0.05 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1800857 Disease Relevance 0 Pain Relevance 0
In contrast to the auditory core region, posterior auditory association areas (PT, PPa) show no significant phase effect indicating that we observed surprisingly strong crossmodal activation.


3 Discussion

Neg (no) Gene_expression (effect) of phase in posterior
8) Confidence 0.05 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1800857 Disease Relevance 0 Pain Relevance 0
Each block corresponded to one particular experimental phase that we introduce in turn.
Gene_expression (introduce) of phase
9) Confidence 0.05 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1800857 Disease Relevance 0 Pain Relevance 0

General Comments

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