INT201261

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.09
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.72
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (AGFG1) transport (AGFG1) Golgi apparatus (AGFG1)
RNA binding (AGFG1) cytoplasmic membrane-bounded vesicle (AGFG1) nucleus (AGFG1)
Anatomy Link Frequency
epithelium 1
AGFG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 48 99.60 Very High Very High Very High
Neurotransmitter 4 99.04 Very High Very High Very High
anesthesia 2 94.08 High High
cocaine 1 45.12 Quite Low
cytokine 2 26.00 Quite Low
Pain 8 11.92 Low Low
Peripheral nervous system 2 7.44 Low Low
addiction 10 5.00 Very Low Very Low Very Low
Opioid 10 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 46 98.76 Very High Very High Very High
Disease 174 96.96 Very High Very High Very High
Mouth Disease 12 96.92 Very High Very High Very High
Charcot Marie Tooth Disease 28 96.36 Very High Very High Very High
Communicable Diseases 2 96.24 Very High Very High Very High
Intellectual Impairment 10 95.76 Very High Very High Very High
Choroideremia 8 95.48 Very High Very High Very High
Diabetes Mellitus 8 95.28 Very High Very High Very High
Blindness 2 93.92 High High
Pigment Disorder 4 85.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the other isoform, REP-2, seems to be sufficient for the geranylgeranylation of all Rab GTPases in all tissues, the retinal pigment epithelium seems to be the exception.
Regulation (geranylgeranylation) of Rab in epithelium
1) Confidence 0.09 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2413085 Disease Relevance 0.82 Pain Relevance 0
There is also evidence that alterations in Rab function play an important role in the progression of multifactorial human diseases, such as infectious diseases and type 2 diabetes.
Regulation (alterations) of Rab associated with diabetes mellitus, communicable diseases and disease
2) Confidence 0.05 Published 2008 Journal Eur J Pediatr Section Abstract Doc Link PMC2413085 Disease Relevance 1.83 Pain Relevance 0.09
Thus, GEF and GAP proteins along with GDI play a critical role in the regulation of the Rab activity cycle.
Regulation (regulation) of Rab
3) Confidence 0.04 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0 Pain Relevance 0
For each of the more than 60 human Rabs, multiple regulatory proteins have evolved to modulate Rab membrane targeting and activity.
Regulation (modulate) of Rab
4) Confidence 0.03 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.07 Pain Relevance 0
The observed increase in rab GDP dissociation inhibitor beta after 72 h of morphine could result in an alteration of the amount of active rab proteins available for neurotransmitter release [23].
Regulation (alteration) of rab associated with neurotransmitter and morphine
5) Confidence 0.01 Published 2006 Journal Proteome Sci Section Body Doc Link PMC1766345 Disease Relevance 0 Pain Relevance 0.81

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox