INT201270

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Context Info
Confidence 0.38
First Reported 2006
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.27
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos1) mitochondrion (Nos1) oxidoreductase activity (Nos1)
plasma membrane (Nos1) cytoskeleton (Nos1) nucleus (Nos1)
Anatomy Link Frequency
brainstem 2
dorsal horn 2
Nos1 (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 45 98.28 Very High Very High Very High
Dorsal horn 12 97.84 Very High Very High Very High
medulla 17 96.72 Very High Very High Very High
Spinal cord 22 86.80 High High
Hippocampus 20 85.52 High High
intrathecal 16 51.36 Quite High
withdrawal 13 51.04 Quite High
Neuronal nitric oxide synthase 3 50.00 Quite Low
Stimulus evoked pain 3 49.88 Quite Low
Peripheral nerve injury 8 45.20 Quite Low
Disease Link Frequency Relevance Heat
Nervous System Injury 73 99.82 Very High Very High Very High
Ganglion Cysts 45 98.28 Very High Very High Very High
Stress 8 80.92 Quite High
Aging 25 80.00 Quite High
Apoptosis 6 73.92 Quite High
Cognitive Disorder 3 71.24 Quite High
Targeted Disruption 18 69.44 Quite High
Alzheimer's Dementia 8 66.44 Quite High
Hypersensitivity 30 61.92 Quite High
Death 5 59.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Concerning the brainstem-sleep structures, our data support the idea that the sleep deterioration observed in the SAMP8, may result from complementary iNOS and nNOS alterations i.e a down-regulation of iNOS [13] concomitant with an activation of nNOS activity at an early age.
Regulation (regulation) of Positive_regulation (activation) of nNOS in brainstem associated with medulla
1) Confidence 0.38 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1766358 Disease Relevance 0.82 Pain Relevance 0.13
In addition, L5 spinal nerve injury did not change the expression level of nNOS in either ipsilateral or contralateral L4 DRG and L4 dorsal horn at day 7 post-nerve injury (data not shown).
Neg (not) Regulation (change) of Neg (not) Positive_regulation (change) of nNOS in dorsal horn associated with dorsal root ganglion, nervous system injury and dorsal horn
2) Confidence 0.23 Published 2007 Journal Mol Pain Section Body Doc Link PMC2089056 Disease Relevance 1.45 Pain Relevance 0.50

General Comments

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