INT201271

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Context Info
Confidence 0.82
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 8
Disease Relevance 4.22
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Snca) mitochondrion (Snca) histone binding (Snca)
plasma membrane (Snca) cytoskeleton (Snca) nucleus (Snca)
Anatomy Link Frequency
ganglia 2
neurons 1
brains 1
ENS 1
Snca (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 43 99.90 Very High Very High Very High
Inflammatory response 12 99.80 Very High Very High Very High
Central nervous system 91 99.44 Very High Very High Very High
anesthesia 1 99.20 Very High Very High Very High
Hippocampus 41 96.52 Very High Very High Very High
Peripheral nervous system 6 93.36 High High
Nerve growth factor 1 92.36 High High
Locus ceruleus 6 90.52 High High
Spinal cord 192 89.64 High High
Substantia nigra 16 78.76 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 55 99.90 Very High Very High Very High
Gliosis 6 99.80 Very High Very High Very High
Stress 31 99.76 Very High Very High Very High
Aging 25 98.76 Very High Very High Very High
Parkinson's Disease 45 98.16 Very High Very High Very High
Apoptosis 6 95.76 Very High Very High Very High
Disease 269 95.04 Very High Very High Very High
Death 29 94.92 High High
Urological Neuroanatomy 146 89.64 High High
Congenital Anomalies 1 86.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SNCA siRNA, luciferase siRNA or PBS was infused at a rate of 0.25 ?
Phosphorylation (infused) of SNCA
1) Confidence 0.82 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2612658 Disease Relevance 0.07 Pain Relevance 0.28
Associated alpha-synuclein phosphorylation and gliosis was confirmed by the presence of GFAP and Ser-129 phosphorylated alpha-synuclein in ENS ganglia from treated (Fig. 1H and 1J) but not control mice (Figure 1G and 1I).
Neg (not) Phosphorylation (phosphorylated) of alpha-synuclein in ganglia associated with gliosis
2) Confidence 0.81 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808242 Disease Relevance 0.21 Pain Relevance 0.03
Associated alpha-synuclein phosphorylation and gliosis was confirmed by the presence of GFAP and Ser-129 phosphorylated alpha-synuclein in ENS ganglia from treated (Fig. 1H and 1J) but not control mice (Figure 1G and 1I).
Phosphorylation (phosphorylation) of alpha-synuclein in ganglia associated with gliosis
3) Confidence 0.81 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808242 Disease Relevance 0.22 Pain Relevance 0.03
These pathological findings are usually associated with an inflammatory response [22] and phosphorylation of the alpha-synuclein (Ser129) which accumulates as a component of LB in the brains of patients with alpha-synucleinopathies [23].
Phosphorylation (phosphorylation) of alpha-synuclein in brains associated with parkinson's disease and inflammatory response
4) Confidence 0.81 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808242 Disease Relevance 1.36 Pain Relevance 0.42
200, BD Pharmigen, CA, USA), rabbit anti-phospho-alpha-synuclein (phospho S129) (1?
Phosphorylation (phospho) of alpha-synuclein
5) Confidence 0.80 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808242 Disease Relevance 0 Pain Relevance 0.09
Moreover, we also observed inflammation and alpha-synuclein phosphorylation in the ENS and DMV.
Phosphorylation (phosphorylation) of alpha-synuclein in ENS associated with inflammation
6) Confidence 0.62 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2808242 Disease Relevance 0.68 Pain Relevance 0.21
We observed alpha-synuclein accumulation, phosphorylation, and inflammatory signs and loss of nigral TH+ neurons in our treated mice after 3 months of the treatment.
Phosphorylation (phosphorylation) of alpha-synuclein in neurons associated with inflammation
7) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808242 Disease Relevance 0.44 Pain Relevance 0.27
Regarding other structures, several indices of oxidative stress as well as alpha synuclein and hyperphosphorylated tau protein could rely to the senescence-related impairments and neurodegeneration in SAMP8 [29].


Phosphorylation (hyperphosphorylated) of alpha synuclein associated with stress and aging
8) Confidence 0.07 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1766358 Disease Relevance 1.24 Pain Relevance 0.12

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