INT201274

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Context Info
Confidence 0.05
First Reported 2006
Last Reported 2006
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.15
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Car2, Nos1) cytosol (Car2, Nos1) mitochondrion (Nos1)
lyase activity (Car2) enzyme binding (Nos1) extracellular space (Car2)
Anatomy Link Frequency
hippocampus 2
Car2 (Mus musculus)
Nos1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 40 97.64 Very High Very High Very High
Glutamate 6 75.92 Quite High
medulla 34 60.64 Quite High
Neuronal nitric oxide synthase 2 50.00 Quite Low
Central nervous system 2 14.76 Low Low
Nerve growth factor 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Pyramidal cell 2 5.00 Very Low Very Low Very Low
Thalamus 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 16 99.86 Very High Very High Very High
Aging 50 99.40 Very High Very High Very High
Death 10 96.68 Very High Very High Very High
Stress 14 92.52 High High
Cognitive Disorder 6 88.16 High High
Drug Induced Neurotoxicity 2 84.80 Quite High
Neurodegenerative Disease 6 27.40 Quite Low
Apoptosis 12 5.00 Very Low Very Low Very Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this sense, it has been reported that: 1- different regions behave differently during aging and/or degeneration [16]; 2- nNOS expression and synthesis can be regulated by Ca2+fluxes independently from nNOS activity especially in the hippocampus [24]; (c) there is a post-transcriptional regulation of nNOS expression in the brain of SAM [17].
Ca2 Neg (independently) Regulation (regulated) of Gene_expression (expression) of nNOS in hippocampus associated with aging and hippocampus
1) Confidence 0.05 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1766358 Disease Relevance 0.32 Pain Relevance 0.25
A dysfunction of Ca2+ homeostasis supports also the link between NO and AD since Ca2+ is the primary regulator of nNOS expression [3].
Ca2 Regulation (regulator) of Gene_expression (expression) of nNOS associated with alzheimer's dementia
2) Confidence 0.03 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1766358 Disease Relevance 0.83 Pain Relevance 0.13

General Comments

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