INT20129

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Context Info
Confidence 0.53
First Reported 1989
Last Reported 2010
Negated 8
Speculated 1
Reported most in Body
Documents 53
Total Number 54
Disease Relevance 44.14
Pain Relevance 19.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
cartilage 2
articular cartilage 2
macrophages 1
peritoneum 1
brain 1
Il1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1169 100.00 Very High Very High Very High
cytokine 1077 100.00 Very High Very High Very High
antagonist 147 100.00 Very High Very High Very High
noradrenaline 10 100.00 Very High Very High Very High
Analgesic 23 99.98 Very High Very High Very High
Arthritis 769 99.74 Very High Very High Very High
chemokine 122 99.52 Very High Very High Very High
long-term potentiation 8 99.40 Very High Very High Very High
opioid receptor 97 99.30 Very High Very High Very High
Inflammatory response 156 99.26 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1315 100.00 Very High Very High Very High
Experimental Arthritis 45 99.84 Very High Very High Very High
Crystal Associated Disease 252 99.76 Very High Very High Very High
Otitis Media 134 99.76 Very High Very High Very High
Frailty 15 99.76 Very High Very High Very High
Arthritis 803 99.74 Very High Very High Very High
Acute Coronary Syndrome 32 99.66 Very High Very High Very High
Pseudomonas Infection 12 99.56 Very High Very High Very High
Cognitive Disorder 161 99.46 Very High Very High Very High
Multiple Organ Failure 8 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased levels of endogenous IL-1ra and IL-1RII are likely to be important mechanisms for regulation of IL-1 activity following brain injury.
Regulation (regulation) of IL-1 in brain associated with brain injury
1) Confidence 0.53 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 1.28 Pain Relevance 0.12
Another hallmark of anti-inflammatory response in the CTX treated mice is the down-regulation of IL1?
Regulation (regulation) of IL1 associated with inflammatory response
2) Confidence 0.44 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2939656 Disease Relevance 0.89 Pain Relevance 0.46
Effect of NF161 and NF177 on IL-1?
Regulation (Effect) of IL-1
3) Confidence 0.44 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1435878 Disease Relevance 0.31 Pain Relevance 0.16
Furthermore, LPS-induced IL-1 production by macrophages (in the absence of added beta-endorphin) was also partially inhibited following treatment with naloxone, suggesting that opioids derived from activated macrophages may also modulate IL-1 generation and secretion.
Regulation (modulate) of IL-1 in macrophages associated with narcan and opioid
4) Confidence 0.40 Published 1989 Journal Int. Immunol. Section Abstract Doc Link 2535139 Disease Relevance 0 Pain Relevance 0.32
Comparisons with animal model studies teach us that continued high dosing is crucial in fully controlling IL-1.
Regulation (controlling) of IL-1
5) Confidence 0.40 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128880 Disease Relevance 0.60 Pain Relevance 0.34
Interestingly, this model seemed to be dependent not on TNF but on IL-1 (personal communication).
Neg (not) Regulation (dependent) of IL-1
6) Confidence 0.40 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128880 Disease Relevance 1.02 Pain Relevance 0.49
The roles of IL-1b and other host genetic factors in the pathogenesis of H pylori related cancer are discussed in this article.
Regulation (roles) of IL-1b associated with cancer and gastritis
7) Confidence 0.36 Published 2003 Journal Can. J. Gastroenterol. Section Abstract Doc Link 12845345 Disease Relevance 1.32 Pain Relevance 0.07
The effectiveness of IL-1 inhibition in hereditary autoinflammatory syndromes with mutations in the NALP3 protein suggested that IL-1 inhibition might also be effective in relieving the inflammatory manifestations of acute gout.
Regulation (effectiveness) of IL-1 associated with inflammation, syndrome and crystal associated disease
8) Confidence 0.31 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1906806 Disease Relevance 0.73 Pain Relevance 0.12
Our results from animal studies confirmed the effectiveness of IL-1 inhibition in preventing neutrophil trafficking to the peritoneum, whereas TNF inhibition did not have any effect.
Regulation (effectiveness) of IL-1 in peritoneum
9) Confidence 0.31 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906806 Disease Relevance 0.99 Pain Relevance 0.37
The effectiveness of IL-1 inhibition was first evaluated in a mouse model of monosodium urate crystal-induced inflammation.
Regulation (effectiveness) of IL-1 associated with inflammation and crystal associated disease
10) Confidence 0.31 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1906806 Disease Relevance 0.92 Pain Relevance 0.22
In vitro, Piroxicam did not affect IL-1 induced thymocyte proliferation (LAF assay).
Neg (not) Regulation (affect) of IL-1 in thymocyte
11) Confidence 0.26 Published 1990 Journal Immunol. Cell Biol. Section Abstract Doc Link 2123471 Disease Relevance 0 Pain Relevance 0.20
In AIA the onset of arthritis is vigorous and at best partly dependent on TNF and IL-1, but the cartilage erosion and propagation of inflammation are dependent on IL-1 [35,36,37,38].
Regulation (dependent) of IL-1 in cartilage associated with inflammation and arthritis
12) Confidence 0.25 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128880 Disease Relevance 1.31 Pain Relevance 0.63
When repeat injections with SCW were given, the inflammation became partly dependent on IL-1, and erosions still developed in TNF-deficient mice and were fully absent in IL-1?
Regulation (dependent) of IL-1 associated with inflammation
13) Confidence 0.17 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128880 Disease Relevance 0.80 Pain Relevance 0.40
The initial studies targeting IL-1 were performed with soluble IL-1 type I receptor.
Regulation (targeting) of IL-1
14) Confidence 0.17 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128880 Disease Relevance 0.87 Pain Relevance 0.58
Self-regulation and inhibition of IL-1?
Regulation (regulation) of IL-1
15) Confidence 0.17 Published 2010 Journal Crit Care Section Body Doc Link PMC2911722 Disease Relevance 0.74 Pain Relevance 0.28
Here we provide evidence that targeting the IL-1 signaling ameliorates cognitive abnormalities that does not directly depend on HMGB-1 mechanisms.
Regulation (targeting) of IL-1 associated with cognitive disorder and congenital anomalies
16) Confidence 0.17 Published 2010 Journal Crit Care Section Body Doc Link PMC2911722 Disease Relevance 1.45 Pain Relevance 0.25
Microglia, in particular, have been shown to locally up regulate IL-1?
Regulation (regulate) of IL-1 in Microglia
17) Confidence 0.15 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC555557 Disease Relevance 0.72 Pain Relevance 0.24
Fatty acid treatment alone did not affect incorporation rates, and the combined IL-1?
Neg (not) Regulation (affect) of IL-1
18) Confidence 0.13 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945020 Disease Relevance 0.18 Pain Relevance 0.09
Recently, the transcription factor T-bet has been shown to modulate antibody-induced arthritis through its regulatory function on IL-1?
Regulation (regulatory) of IL-1 associated with arthritis
19) Confidence 0.12 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794524 Disease Relevance 1.34 Pain Relevance 0.82
The beneficial effects on cognition reported in this study by targeting IL-1, preemptively, are encouraging.
Regulation (targeting) of IL-1 associated with cognitive disorder
20) Confidence 0.10 Published 2010 Journal Crit Care Section Body Doc Link PMC2911722 Disease Relevance 0.94 Pain Relevance 0.22

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