INT201307

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.71
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Vcan) extracellular region (Vcan) proteinaceous extracellular matrix (Vcan)
Anatomy Link Frequency
blood 1
nerve 1
Vcan (Mus musculus)
Pain Link Frequency Relevance Heat
Sciatic nerve 100 98.30 Very High Very High Very High
Spinal cord 30 92.48 High High
Dorsal column 54 85.48 High High
Inflammation 3 78.48 Quite High
dorsal root ganglion 62 56.24 Quite High
5HT 2 43.52 Quite Low
Peripheral nerve injury 10 5.00 Very Low Very Low Very Low
withdrawal 10 5.00 Very Low Very Low Very Low
halothane 6 5.00 Very Low Very Low Very Low
unmyelinated 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Weight Loss 5 100.00 Very High Very High Very High
Targeted Disruption 158 99.96 Very High Very High Very High
Confusion 2 99.24 Very High Very High Very High
Encephalopathy 14 98.86 Very High Very High Very High
Body Weight 5 95.64 Very High Very High Very High
Frailty 6 92.76 High High
Injury 97 85.76 High High
Dyslipidemia /

Combined Dyslipidemia

1 79.92 Quite High
Anaemia 2 79.36 Quite High
Appetite Loss 3 79.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, such enzymatic degradation is not specific to NG2 and will affect many other molecules with potential axon growth inhibiting properties and it is relevant that there are strongly inhibitory domains in the NG2 core protein which would be unaffected by treatment with chondroitinase ABC [7].
Neg (unaffected) Negative_regulation (unaffected) of NG2
1) Confidence 0.41 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2100060 Disease Relevance 0.14 Pain Relevance 0.09
In addition, we have shown, by quantitative methods and for the first time, that sciatic nerve fibres, both motor and sensory, and facial (motor) nerve fibres, regenerated and re-established functional innervation of target tissues to the same extent and at the same speed in the NG2 knockout and wild-type groups.
Negative_regulation (established) of NG2 in nerve associated with targeted disruption and sciatic nerve
2) Confidence 0.35 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2100060 Disease Relevance 0.60 Pain Relevance 0.30
If the patient recovered from encephalopathy and disorientation disappeared, the duration of on-line HDF was reduced to two-thirds of the initial duration, and if consciousness was maintained under this condition, on-line HDF was given once per 2 days.


Negative_regulation (reduced) of HDF associated with encephalopathy and confusion
3) Confidence 0.30 Published 2010 Journal BMC Emerg Med Section Body Doc Link PMC2898817 Disease Relevance 0.29 Pain Relevance 0
The higher the hydraulic permeability, the higher is the backfiltration risk; this process could be limited both by permanent convective flow from the blood compartment to the dialysate compartment, as ultrafiltration (HF, HDF, or at least weight loss) and by use of ultrapure dialysate.
Negative_regulation (loss) of HDF in blood associated with weight loss
4) Confidence 0.01 Published 2005 Journal Pediatr Nephrol Section Body Doc Link PMC1766474 Disease Relevance 0.60 Pain Relevance 0.04

General Comments

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