INT20131

Context Info Confidence 0.57 First Reported 1981 Last Reported 2005 Negated 0 Speculated 0 Reported most in Abstract Documents 18 Total Number 18 Disease Relevance 7.93 Pain Relevance 10.54

mitochondrion (Mthfs) Golgi apparatus (Mthfs) plasma membrane (Mthfs) ligase activity (Mthfs) cytoplasm (Mthfs)

Anatomy Link Frequency plasma 1 macrophages 1 lymphocyte 1 respiratory 1 body 1 Mthfs (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 65 99.92 cytokine 9 99.92 cINOD 43 99.72 Analgesic 19 99.70 aspirin 61 99.36 Paracetamol 10 99.36 Antinociceptive 40 98.16 analgesia 4 98.02 Bioavailability 2 98.00 Neurotransmitter 1 92.48

Disease Link Frequency Relevance Heat INFLAMMATION 78 99.66 Toxicity 7 98.84 Cancer 6 98.08 Disease 2 98.02 Epilepsy 6 97.92 Neurological Disease 1 96.76 Hypersensitivity 5 96.56 Brain Disease 1 96.24 Colon Cancer 1 95.60 Injury 3 94.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

On the basis of these results it may be suggested that inhibition of the cyclo-oxygenase reaction has no major effect on the early phase in the formalin test.

Negative_regulation (inhibition) of cyclo-oxygenase

1) Confidence 0.57 Published 1986 Journal Pain Section Abstract Doc Link 3714284 Disease Relevance 0.31 Pain Relevance 0.74

Probably, its mechanism of action could be explained through the inhibition to cyclo-oxygenase activity.

Negative_regulation (inhibition) of cyclo-oxygenase

2) Confidence 0.57 Published 2003 Journal Bioorg. Med. Chem. Section Abstract Doc Link 12628645 Disease Relevance 0.61 Pain Relevance 0.70

It is assumed that the mild analgesia produced by acetylsalicylic acid (ASA) and indomethacin is due to a common mode of action, namely inhibition of the cyclo-oxygenase reaction in the synthesis of prostaglandins.

Negative_regulation (inhibition) of cyclo-oxygenase associated with aspirin and analgesia

3) Confidence 0.42 Published 1986 Journal Pain Section Abstract Doc Link 3714284 Disease Relevance 0.32 Pain Relevance 0.54

It is a well-established fact that NSAIDs exert their analgesic and anti-inflammatory activity by the inhibition of cyclo-oxygenase activity [23].

Negative_regulation (inhibition) of cyclo-oxygenase associated with inflammation, analgesic and cinod

4) Confidence 0.38 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC101384 Disease Relevance 0.87 Pain Relevance 1.44

Aspirin (ASA) is widely used oral analgesics and acts as an inhibitor of cyclo-oxygenase.

Negative_regulation (inhibitor) of cyclo-oxygenase associated with aspirin and analgesic

5) Confidence 0.30 Published 2001 Journal Brain Res. Section Abstract Doc Link 11720731 Disease Relevance 0.26 Pain Relevance 1.20

Effect of naproxen, a non-selective cyclo-oxygenase inhibitor, on pentylenetetrazol-induced kindling in mice.

Negative_regulation (inhibitor) of cyclo-oxygenase

6) Confidence 0.14 Published 2005 Journal Clin. Exp. Pharmacol. Physiol. Section Title Doc Link 16026518 Disease Relevance 0.82 Pain Relevance 0.22

This activity is not associated with inhibition of cyclo-oxygenase.

Negative_regulation (inhibition) of cyclo-oxygenase

7) Confidence 0.11 Published 1981 Journal Agents Actions Section Abstract Doc Link 6456651 Disease Relevance 0.85 Pain Relevance 0.28

Although nimesulide is not a cyclo-oxygenase inhibitor in gastric tissues or bovine seminal vesicle microsomes, it inhibits prostaglandin synthesis in zymosan-stimulated murine macrophages in inflammatory exudate.

Negative_regulation (inhibitor) of cyclo-oxygenase in macrophages associated with inflammation

8) Confidence 0.10 Published 1993 Journal Drugs Section Abstract Doc Link 7506143 Disease Relevance 0.28 Pain Relevance 0.38

The NSAIDs, indomethacin ibuprofen, flurbiprofen, and benoxaprofen, were analgesic and selective cyclo-oxygenase inhibitors.

Negative_regulation (inhibitors) of cyclo-oxygenase associated with analgesic and cinod

9) Confidence 0.04 Published 1988 Journal J Pharmacol Methods Section Abstract Doc Link 3145369 Disease Relevance 0 Pain Relevance 0.57

Nitric oxide mediated effect of cyclo-oxygenase inhibitors.

Negative_regulation (inhibitors) of cyclo-oxygenase associated with aspirin

10) Confidence 0.03 Published 2001 Journal J Pak Med Assoc Section Title Doc Link 11255995 Disease Relevance 0.29 Pain Relevance 0.24

The cyclo-oxygenase inhibitor, piroxicam, enhances cytokine-induced lymphocyte proliferation in vitro and in vivo.

Negative_regulation (inhibitor) of cyclo-oxygenase in lymphocyte associated with cytokine

11) Confidence 0.02 Published 1990 Journal Immunol. Cell Biol. Section Title Doc Link 2123471 Disease Relevance 0.06 Pain Relevance 0.55

Unlike its parent compound, this metabolite lacks cyclo-oxygenase inhibitory activity.

Negative_regulation (lacks) of cyclo-oxygenase

12) Confidence 0.02 Published 1998 Journal Carcinogenesis Section Abstract Doc Link 9744528 Disease Relevance 0.63 Pain Relevance 0.14

The advent of selective inhibitors of the cyclo-oxygenase (COX)-2 enzyme has afforded the opportunity to reduce the incidence of gastrointestinal complications of traditional nonsteroidal anti-inflammatory drugs (NSAIDs).

Negative_regulation (inhibitors) of cyclo-oxygenase associated with inflammation and cinod

13) Confidence 0.01 Published 2000 Journal Ann. Med. Section Abstract Doc Link 11209977 Disease Relevance 0.23 Pain Relevance 0.22

Epidemiological studies have shown that the risk of developing Alzheimer's disease is reduced by the chronic use of classical non-steroidal anti-inflammatory drugs (NSAIDs), drugs that inhibit the cyclo-oxygenase (COX) enzymes that convert arachidonic acid to prostaglandins.

Negative_regulation (inhibit) of cyclo-oxygenase associated with inflammation, cinod and disease

14) Confidence 0.01 Published 2003 Journal Neuroreport Section Abstract Doc Link 14600505 Disease Relevance 0.63 Pain Relevance 0.29

NO-NSAIDs are nonselective cyclo-oxygenase (COX) inhibitors, and they also exert COX-independent activities that are NO-dependent.

Negative_regulation (inhibitors) of cyclo-oxygenase associated with cinod

15) Confidence 0.01 Published 2001 Journal Drug Saf Section Abstract Doc Link 11665868 Disease Relevance 0.58 Pain Relevance 1.47

The systemic activity comprises the inhibition of cyclo-oxygenase, but an increasing body of evidence suggests that cyclo-oxygenase-independent mechanisms are involved in the development of gastric injury.

Negative_regulation (inhibition) of cyclo-oxygenase in body associated with injury

16) Confidence 0.01 Published 2001 Journal Dig Liver Dis Section Abstract Doc Link 11827361 Disease Relevance 0.74 Pain Relevance 0.37

In conclusion, the plasma levels of ASA reached at the time of a positive reaction are of the magnitude known to inhibit cyclo-oxygenases.

Negative_regulation (inhibit) of cyclo-oxygenases in plasma associated with aspirin

17) Confidence 0.01 Published 1994 Journal Allergy Section Abstract Doc Link 8198239 Disease Relevance 0.26 Pain Relevance 0.80

BACKGROUND: Patients with aspirin-sensitive respiratory and cutaneous diseases experience cross reactions to all nonsteroidal anti-inflammatory drugs (NSAIDs) which inhibit cyclo-oxigenase (COX) enzymes.

Negative_regulation (inhibit) of cyclo-oxigenase in respiratory associated with aspirin, inflammation, cinod and disease

18) Confidence 0.00 Published 2004 Journal Eur Ann Allergy Clin Immunol Section Abstract Doc Link 15329003 Disease Relevance 0.20 Pain Relevance 0.41

General Comments

This test has worked.