INT201313

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Context Info
Confidence 0.75
First Reported 2006
Last Reported 2010
Negated 5
Speculated 1
Reported most in Body
Documents 27
Total Number 28
Disease Relevance 16.63
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MX1) signal transduction (MX1) GTPase activity (MX1)
cytoplasm (MX1)
Anatomy Link Frequency
PSN1 3
blood 1
external 1
A549 1
mononuclear cells 1
MX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 26 90.92 High High
chemokine 48 81.24 Quite High
Inflammation 72 80.80 Quite High
Chronic pancreatitis 144 58.56 Quite High
anesthesia 2 33.20 Quite Low
cytokine 25 5.00 Very Low Very Low Very Low
tolerance 23 5.00 Very Low Very Low Very Low
Central nervous system 15 5.00 Very Low Very Low Very Low
Neuropeptide 11 5.00 Very Low Very Low Very Low
projection neuron 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Influenza Virus Infection 98 100.00 Very High Very High Very High
Cancer 912 99.86 Very High Very High Very High
Adenocarcinoma 984 99.72 Very High Very High Very High
Pancreatic Cancer 192 98.60 Very High Very High Very High
Viral Infection 122 98.48 Very High Very High Very High
Infection 205 98.24 Very High Very High Very High
Congenital Anomalies 39 96.68 Very High Very High Very High
Hypoxia 51 94.88 High High
Malignant Neoplastic Disease 24 94.04 High High
Breast Cancer 24 89.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NAB levels in the plasma samples of day 77 were assessed in a bioassay based on inhibition of induction of myxovirus resistance protein A (MxA) gene expression in an A549 cell line as previously described (21).
Gene_expression (expression) of MxA in A549 associated with influenza virus infection
1) Confidence 0.75 Published 2010 Journal Pharm Res Section Body Doc Link PMC2916121 Disease Relevance 0.10 Pain Relevance 0
Both MxA and a control household gene-derived mRNA (eukaryotic 18S rRNA) were detected with a real-time RT-PCR multiplex assay.
Gene_expression (detected) of MxA
2) Confidence 0.75 Published 2010 Journal Pharm Res Section Body Doc Link PMC2916121 Disease Relevance 0.09 Pain Relevance 0
The existence of two diverse molecular phenotypes of PDAC based on the expression of MxA was confirmed in an independent set of 23 primary PDACs by immunohistochemistry.
Gene_expression (expression) of MxA associated with adenocarcinoma
3) Confidence 0.57 Published 2010 Journal J Transl Med Section Body Doc Link PMC2845551 Disease Relevance 0.58 Pain Relevance 0
Interestingly, all the experiments were performed on cell lines that were negative for the MxA expression.
Gene_expression (expression) of MxA
4) Confidence 0.57 Published 2010 Journal J Transl Med Section Body Doc Link PMC2845551 Disease Relevance 0.54 Pain Relevance 0
To assess the functional relevance of the anti-viral state, we screened 10 PDAC cell lines for MxA expression.
Gene_expression (expression) of MxA associated with adenocarcinoma
5) Confidence 0.57 Published 2010 Journal J Transl Med Section Body Doc Link PMC2845551 Disease Relevance 0.73 Pain Relevance 0
As positive control for MxA expression, peripheral blood mononuclear cells from healthy donors were incubated overnight with IFN-alpha at a final concentration of 100 IU/ml.


Gene_expression (expression) of MxA in mononuclear cells
6) Confidence 0.57 Published 2010 Journal J Transl Med Section Body Doc Link PMC2845551 Disease Relevance 0.28 Pain Relevance 0
MxA expression by immunohistochemical and Western blot were concordant with transcriptional analysis showing that four of 11 xenografts (36%) displayed an anti-viral phenotype (Figure 3D).
Gene_expression (expression) of MxA
7) Confidence 0.57 Published 2010 Journal J Transl Med Section Body Doc Link PMC2845551 Disease Relevance 0.31 Pain Relevance 0
To assess whether MxA expression influences cancer cell permissivity to the infection by viruses other then adenovirus, we tested the transduction properties of the Adeno Associated Virus (AAV) types 5 and 6 on 8 representative PDAC cell lines (Figure 5F).
Spec (whether) Gene_expression (expression) of MxA associated with adenocarcinoma, cancer and infection
8) Confidence 0.57 Published 2010 Journal J Transl Med Section Body Doc Link PMC2845551 Disease Relevance 1.03 Pain Relevance 0
MxA expression discriminates the two ISG-related molecular phenotypes of PDAC
Gene_expression (expression) of MxA associated with adenocarcinoma
9) Confidence 0.57 Published 2010 Journal J Transl Med Section Body Doc Link PMC2845551 Disease Relevance 0.24 Pain Relevance 0
Also in this case, cell lines expressing MxA were much less prone to transduction than MxA negative cells.


Gene_expression (expressing) of MxA
10) Confidence 0.49 Published 2010 Journal J Transl Med Section Body Doc Link PMC2845551 Disease Relevance 0.71 Pain Relevance 0
Ten (43%) PDACs stained positively for MxA (Figure 4A); three had over 80% of cancer cells expressing MxA while seven had a positivity ranging from 25% to 60%.
Gene_expression (expressing) of MxA associated with cancer
11) Confidence 0.49 Published 2010 Journal J Transl Med Section Body Doc Link PMC2845551 Disease Relevance 0.63 Pain Relevance 0
Cell lines that did not express MxA were more prone to the cytopathic effects and more permissive to viral replication than those expressing MxA (Figure 5B and 5C).
Gene_expression (expressing) of MxA
12) Confidence 0.49 Published 2010 Journal J Transl Med Section Body Doc Link PMC2845551 Disease Relevance 1.00 Pain Relevance 0
Cell lines that did not express MxA were more prone to the cytopathic effects and more permissive to viral replication than those expressing MxA (Figure 5B and 5C).
Neg (not) Gene_expression (express) of MxA
13) Confidence 0.49 Published 2010 Journal J Transl Med Section Body Doc Link PMC2845551 Disease Relevance 0.97 Pain Relevance 0
Ten (43%) PDACs stained positively for MxA (Figure 4A); three had over 80% of cancer cells expressing MxA while seven had a positivity ranging from 25% to 60%.
Gene_expression (stained) of MxA associated with cancer
14) Confidence 0.49 Published 2010 Journal J Transl Med Section Body Doc Link PMC2845551 Disease Relevance 0.62 Pain Relevance 0
Western Blot analysis discriminated cancer cell lines into MxA positive (PaCa44, HPAFI, CFPAC, PSN1) or MxA negative (Ger, PT45, Panc1, Panc2, MiaPaCa2, PaCa3) (Figure 5A).
Neg (negative) Gene_expression (negative) of MxA in PSN1 associated with cancer
15) Confidence 0.49 Published 2010 Journal J Transl Med Section Body Doc Link PMC2845551 Disease Relevance 0.67 Pain Relevance 0
Western Blot analysis discriminated cancer cell lines into MxA positive (PaCa44, HPAFI, CFPAC, PSN1) or MxA negative (Ger, PT45, Panc1, Panc2, MiaPaCa2, PaCa3) (Figure 5A).
Neg (negative) Gene_expression (positive) of MxA in PSN1 associated with cancer
16) Confidence 0.49 Published 2010 Journal J Transl Med Section Body Doc Link PMC2845551 Disease Relevance 0.73 Pain Relevance 0
Western Blot analysis discriminated cancer cell lines into MxA positive (PaCa44, HPAFI, CFPAC, PSN1) or MxA negative (Ger, PT45, Panc1, Panc2, MiaPaCa2, PaCa3) (Figure 5A).
Neg (negative) Gene_expression (negative) of MxA in PSN1 associated with cancer
17) Confidence 0.49 Published 2010 Journal J Transl Med Section Body Doc Link PMC2845551 Disease Relevance 0.73 Pain Relevance 0
As shown in Figure 6A all four MxA-expressing cell lines demonstrated spontaneous activation of the ISRE promoter independently of external stimulus while no constitutive activation for the IFN-beta promoter was seen.
Gene_expression (expressing) of MxA in external
18) Confidence 0.44 Published 2010 Journal J Transl Med Section Body Doc Link PMC2845551 Disease Relevance 0.62 Pain Relevance 0
In this study, we identified by transcriptional profiling two ISG-defined phenotypes of pancreatic cancer that are readily recognized by immunohistochemistry according to the expression of MxA as a marker of IFN activity.
Gene_expression (expression) of MxA associated with pancreatic cancer
19) Confidence 0.44 Published 2010 Journal J Transl Med Section Body Doc Link PMC2845551 Disease Relevance 1.05 Pain Relevance 0.11
Among the ISGs differentially expressed between the two PDACs phenotypes, MxA was selected as marker for the "anti-viral phenotype" since this protein is directly associated with anti-viral properties [30].
Gene_expression (selected) of MxA
20) Confidence 0.44 Published 2010 Journal J Transl Med Section Body Doc Link PMC2845551 Disease Relevance 0.24 Pain Relevance 0

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