INT20133

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Context Info
Confidence 0.78
First Reported 1980
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 23
Total Number 24
Disease Relevance 2.04
Pain Relevance 5.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Trh, Prl) plasma membrane (Trh) nucleus (Trh)
cytoplasm (Trh)
Anatomy Link Frequency
thyroid 2
pituitary 2
anterior pituitary 2
Trh (Rattus norvegicus)
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 6 100.00 Very High Very High Very High
local anesthetic 8 99.78 Very High Very High Very High
antagonist 93 99.44 Very High Very High Very High
opiate 8 99.22 Very High Very High Very High
agonist 59 99.02 Very High Very High Very High
lidocaine 7 98.92 Very High Very High Very High
dopamine receptor 10 98.28 Very High Very High Very High
Serotonin 16 98.24 Very High Very High Very High
Dopamine 36 98.08 Very High Very High Very High
Potency 12 96.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 112 100.00 Very High Very High Very High
Cancer 46 99.52 Very High Very High Very High
Starvation 24 99.20 Very High Very High Very High
Bordatella Infection 10 84.64 Quite High
Sprains And Strains 3 78.00 Quite High
Vibrio Infection 4 76.88 Quite High
Infection 2 60.60 Quite High
Pituitary Cancer 23 52.64 Quite High
INFLAMMATION 56 5.00 Very Low Very Low Very Low
Targeted Disruption 44 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that the dopaminergic and cholinergic systems can modify TRH-induced release of PRL in vivo.
TRH Positive_regulation (induced) of Localization (release) of PRL
1) Confidence 0.78 Published 1986 Journal Life Sci. Section Abstract Doc Link 2934599 Disease Relevance 0 Pain Relevance 0.38
Effect of CNS-active drugs on TRH-induced prolactin release.
TRH Positive_regulation (induced) of Localization (release) of prolactin
2) Confidence 0.78 Published 1986 Journal Life Sci. Section Title Doc Link 2934599 Disease Relevance 0 Pain Relevance 0.39
Pre-treatment with either the dopamine agonist, piribedil, or the cholinergic agonist, pilocarpine, resulted in significantly reduced TRH-induced PRL release.
TRH Positive_regulation (induced) of Localization (release) of PRL associated with dopamine and agonist
3) Confidence 0.78 Published 1986 Journal Life Sci. Section Abstract Doc Link 2934599 Disease Relevance 0 Pain Relevance 0.42
These results suggest that TRH not only stimulates PRL secretion by acting directly at the pituitary, but has an inhibitory action on PRL release through activation of the central dopaminergic mechanism.
TRH Positive_regulation (stimulates) of Localization (secretion) of PRL in pituitary
4) Confidence 0.68 Published 1985 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 3921974 Disease Relevance 0 Pain Relevance 0.21
It is known that TRH not only stimulates TSH secretion but will stimulate prolactin secretion as well.
TRH Positive_regulation (stimulate) of Localization (secretion) of prolactin
5) Confidence 0.64 Published 1980 Journal Neuroendocrinology Section Abstract Doc Link 6775240 Disease Relevance 0.27 Pain Relevance 0.05
Lidocaine inhibits dispersed anterior pituitary cell thyrotropin and prolactin secretion induced by thyrotropin-releasing hormone or high medium potassium.
thyrotropin-releasing hormone Positive_regulation (induced) of Localization (secretion) of prolactin in anterior pituitary associated with lidocaine
6) Confidence 0.55 Published 1989 Journal Neuroendocrinology Section Title Doc Link 2514396 Disease Relevance 0 Pain Relevance 0.52
In starved rats, TRH-Gly apparently stimulated TSH and PRL secretion in a dose-dependent manner, and the stimulatory activity increased in starved rats as compared to normal controls.
TRH-Gly Positive_regulation (stimulated) of Localization (secretion) of PRL
7) Confidence 0.55 Published 1990 Journal Neuropeptides Section Abstract Doc Link 2123526 Disease Relevance 0.07 Pain Relevance 0.13
In starved rats, TRH-Gly apparently stimulated TSH and PRL secretion in a dose-dependent manner, and the stimulatory activity increased in starved rats as compared to normal controls.
TRH-Gly Positive_regulation (stimulated) of Localization (secretion) of PRL
8) Confidence 0.55 Published 1990 Journal Neuropeptides Section Abstract Doc Link 2123526 Disease Relevance 0.07 Pain Relevance 0.13
Local anesthetics inhibited TRH-stimulated PRL release and also inhibited basal PRL secretion and secretion stimulated by two nonhormonal secretagogues, (Bu)2cAMP and a phorbol ester.
TRH-stimulated Positive_regulation (stimulated) of Localization (release) of PRL associated with local anesthetic
9) Confidence 0.53 Published 1989 Journal Mol. Endocrinol. Section Abstract Doc Link 2558307 Disease Relevance 0.05 Pain Relevance 0.64
Pilocarpine did not inhibit the TRH-induced increase in PRL release when rats were first pre-treated with the dopamine receptor blocker, haloperidol.
TRH Positive_regulation (increase) of Localization (release) of PRL associated with dopamine receptor
10) Confidence 0.52 Published 1986 Journal Life Sci. Section Abstract Doc Link 2934599 Disease Relevance 0 Pain Relevance 0.41
Administration of the serotonin antagonist, p-chlorophenylalanine, or the opiate antagonist, naltrexone, did not alter TRH-induced release of PRL.
TRH Positive_regulation (induced) of Localization (release) of PRL associated with antagonist, opiate and serotonin
11) Confidence 0.52 Published 1986 Journal Life Sci. Section Abstract Doc Link 2934599 Disease Relevance 0 Pain Relevance 0.43
The effects of several central acting drugs upon thyrotropin-releasing hormone (TRH)-induced increases in prolactin (PRL) release were compared in estrogen-primed male rats.
TRH Positive_regulation (increases) of Localization (release) of PRL
12) Confidence 0.52 Published 1986 Journal Life Sci. Section Abstract Doc Link 2934599 Disease Relevance 0 Pain Relevance 0.38
Stimulation by a TRH precursor, TRH-Gly, of TSH and PRL secretion in rats: effect of starvation.
TRH Positive_regulation (Stimulation) of Localization (secretion) of PRL associated with starvation
13) Confidence 0.51 Published 1990 Journal Neuropeptides Section Title Doc Link 2123526 Disease Relevance 0.10 Pain Relevance 0.13
Stimulation by a TRH precursor, TRH-Gly, of TSH and PRL secretion in rats: effect of starvation.
TRH-Gly Positive_regulation (Stimulation) of Localization (secretion) of PRL associated with starvation
14) Confidence 0.51 Published 1990 Journal Neuropeptides Section Title Doc Link 2123526 Disease Relevance 0.10 Pain Relevance 0.13
Since ether exposure appears to stimulate prolactin secretion in both estradiol-primed and non-primed male rats through PRF secretion, while TRH was not able to stimulate a significant amount of prolactin secretion in the normal male rat, we concluded that TRH acts to stimulate prolactin secretion in estradiol-primed rats but through a different mechanism than that operating for PRF.
TRH Positive_regulation (stimulate) of Localization (secretion) of prolactin
15) Confidence 0.47 Published 1980 Journal Neuroendocrinology Section Abstract Doc Link 6775240 Disease Relevance 0.13 Pain Relevance 0
Since ether exposure appears to stimulate prolactin secretion in both estradiol-primed and non-primed male rats through PRF secretion, while TRH was not able to stimulate a significant amount of prolactin secretion in the normal male rat, we concluded that TRH acts to stimulate prolactin secretion in estradiol-primed rats but through a different mechanism than that operating for PRF.
TRH Positive_regulation (stimulate) of Localization (secretion) of prolactin
16) Confidence 0.47 Published 1980 Journal Neuroendocrinology Section Abstract Doc Link 6775240 Disease Relevance 0.07 Pain Relevance 0
Comparative studies of prolactin secretion in estradiol-primed and normal male rats induced by ether stress, pimozide and TRH.
TRH Positive_regulation (induced) of Localization (secretion) of prolactin associated with stress
17) Confidence 0.47 Published 1980 Journal Neuroendocrinology Section Title Doc Link 6775240 Disease Relevance 0.34 Pain Relevance 0.09
These effects could be dissociated from GHRP-6-induced GH release in the same animals, but not from PRL release induced by TRH, which was also abolished by ovariectomy and induced in males by E2 treatment.
TRH Positive_regulation (induced) of Localization (release) of PRL
18) Confidence 0.45 Published 1998 Journal Endocrinology Section Abstract Doc Link 9681512 Disease Relevance 0 Pain Relevance 0
Vasointestinal polypeptide (VIP) and thyroliberin (TRH) stimulate prolactin secretion directly.
TRH Positive_regulation (stimulate) of Localization (retion di) of prolactin
19) Confidence 0.38 Published 1985 Journal J. Clin. Chem. Clin. Biochem. Section Abstract Doc Link 3840196 Disease Relevance 0.08 Pain Relevance 0.24
The results suggest a role for VIP, but not TRH, in opioid peptide stimulated release of prolactin.
TRH Positive_regulation (role) of Localization (release) of prolactin associated with opioid
20) Confidence 0.38 Published 1987 Journal Life Sci. Section Abstract Doc Link 3102870 Disease Relevance 0 Pain Relevance 0.53

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