INT201346

Context Info Confidence 0.32 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 4 Disease Relevance 2.10 Pain Relevance 0.05

Anatomy Link Frequency macrophages 2 mature B cells 2 memory B cell 2 follicular B cells 2 Cd19 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 47 50.52 Inflammation 4 50.12 chemokine 3 5.00 spastic colon 2 5.00 Central nervous system 2 5.00 ketamine 2 5.00 Pain 2 5.00 Neurotransmitter 2 5.00 anesthesia 1 5.00 Serotonin 1 5.00

Disease Link Frequency Relevance Heat Infection 251 99.38 Hematological Disease 8 98.46 Splenomegaly 5 97.44 Hypergammaglobulinemia 9 96.56 Apoptosis 7 96.08 Targeted Disruption 4 92.32 Parasitemia 26 72.88 Frailty 2 61.60 Epstein-barr Virus 24 56.48 Sprains And Strains 9 56.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Altogether, these results suggest that the process of B cell hematopoiesis is disturbed in the bone marrow and may be instrumental in the subsequently diminishing production of mature B cells (CD19+IgM+CD43?)

Negative_regulation (diminishing) of Gene_expression (production) of CD19 in mature B cells associated with hematological disease

1) Confidence 0.32 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2919407 Disease Relevance 0.78 Pain Relevance 0

Our studies provide further evidence that the mouse infection with T. vivax causes a marked reduction in the spleen of both B220+CD19+IgM+/hiIgDlo (MZB) and B220+CD19+IgMlo/hiIgDhi follicular B cells.

Negative_regulation (reduction) of Gene_expression (follicular B cells) of CD19 in follicular B cells associated with infection

2) Confidence 0.32 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2919407 Disease Relevance 0.68 Pain Relevance 0.05

The cells retained CD19 and sIgG expression, suggesting differentiation to a pre-plasma memory B cell phenotype.

Negative_regulation (retained) of Gene_expression (expression) of CD19 in memory B cell

3) Confidence 0.25 Published 2008 Journal PLoS Pathogens Section Abstract Doc Link PMC2270344 Disease Relevance 0.29 Pain Relevance 0

expression was maintained on CD3+ T cells, CD19+ B cells (Figure 1D), and macrophages (unpublished data) in smooth muscle cell–specific IL-4R?

Negative_regulation (maintained) of Gene_expression (expression) of CD19 in macrophages

4) Confidence 0.20 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.34 Pain Relevance 0

General Comments

This test has worked.