INT201346

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Context Info
Confidence 0.32
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.10
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
macrophages 2
mature B cells 2
memory B cell 2
follicular B cells 2
Cd19 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 47 50.52 Quite High
Inflammation 4 50.12 Quite High
chemokine 3 5.00 Very Low Very Low Very Low
spastic colon 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Serotonin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 251 99.38 Very High Very High Very High
Hematological Disease 8 98.46 Very High Very High Very High
Splenomegaly 5 97.44 Very High Very High Very High
Hypergammaglobulinemia 9 96.56 Very High Very High Very High
Apoptosis 7 96.08 Very High Very High Very High
Targeted Disruption 4 92.32 High High
Parasitemia 26 72.88 Quite High
Frailty 2 61.60 Quite High
Epstein-barr Virus 24 56.48 Quite High
Sprains And Strains 9 56.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Altogether, these results suggest that the process of B cell hematopoiesis is disturbed in the bone marrow and may be instrumental in the subsequently diminishing production of mature B cells (CD19+IgM+CD43?)
Negative_regulation (diminishing) of Gene_expression (production) of CD19 in mature B cells associated with hematological disease
1) Confidence 0.32 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2919407 Disease Relevance 0.78 Pain Relevance 0
Our studies provide further evidence that the mouse infection with T. vivax causes a marked reduction in the spleen of both B220+CD19+IgM+/hiIgDlo (MZB) and B220+CD19+IgMlo/hiIgDhi follicular B cells.
Negative_regulation (reduction) of Gene_expression (follicular B cells) of CD19 in follicular B cells associated with infection
2) Confidence 0.32 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2919407 Disease Relevance 0.68 Pain Relevance 0.05
The cells retained CD19 and sIgG expression, suggesting differentiation to a pre-plasma memory B cell phenotype.
Negative_regulation (retained) of Gene_expression (expression) of CD19 in memory B cell
3) Confidence 0.25 Published 2008 Journal PLoS Pathogens Section Abstract Doc Link PMC2270344 Disease Relevance 0.29 Pain Relevance 0
expression was maintained on CD3+ T cells, CD19+ B cells (Figure 1D), and macrophages (unpublished data) in smooth muscle cell–specific IL-4R?
Negative_regulation (maintained) of Gene_expression (expression) of CD19 in macrophages
4) Confidence 0.20 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.34 Pain Relevance 0

General Comments

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