INT201347

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Context Info
Confidence 0.30
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.48
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrm3) plasma membrane (Chrm3) signal transducer activity (Chrm3)
Anatomy Link Frequency
uterus 2
goblet cell 2
Chrm3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 50 97.00 Very High Very High Very High
Neurotransmitter 4 66.12 Quite High
Serotonin 2 57.84 Quite High
Potency 16 50.00 Quite Low
adenocard 1 45.28 Quite Low
antagonist 20 33.92 Quite Low
Inflammation 21 5.00 Very Low Very Low Very Low
agonist 11 5.00 Very Low Very Low Very Low
rheumatoid arthritis 5 5.00 Very Low Very Low Very Low
Chronic pancreatitis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperplasia 31 99.12 Very High Very High Very High
Targeted Disruption 113 98.56 Very High Very High Very High
Disorders Of The Lacrimal System 29 97.88 Very High Very High Very High
Infection 72 95.72 Very High Very High Very High
Disease 44 92.72 High High
Syndrome 77 92.20 High High
Nematode Infection 16 91.92 High High
Sprains And Strains 23 91.08 High High
Diabetes Mellitus 22 85.72 High High
Helminth Infection 50 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
wks of age, then accompanied by the production of autoantibodies to nuclear antigens (SSA/Ro, SSB/La) and M3R in the absence of T1D.
Negative_regulation (absence) of Gene_expression (production) of M3R
1) Confidence 0.30 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3018660 Disease Relevance 1.40 Pain Relevance 0.04
As such, our demonstration of significant inhibition of M3 expression in IL-4R?
Negative_regulation (inhibition) of Gene_expression (expression) of M3
2) Confidence 0.24 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.27 Pain Relevance 0.03
The competitive antagonism of the muscarinic contractile response of wild-type uterus resembles an M3 profile, but the Emax for contraction is inhibited by about 50% in uterus from the M2 knockout (KO) mouse.
Negative_regulation (inhibited) of Gene_expression (profile) of M3 in uterus associated with targeted disruption
3) Confidence 0.23 Published 2009 Journal Naunyn Schmiedebergs Arch Pharmacol Section Body Doc Link PMC2749929 Disease Relevance 0.29 Pain Relevance 0
Depressed M3 receptor expression, delayed goblet cell hyperplasia, disruption of CD4+ MLNs, and intestinal cytokine production provide compelling evidence for an important role in the induction of both physiological effector mechanisms and immunological mediators of expulsion.
Negative_regulation (Depressed) of Gene_expression (expression) of M3 in goblet cell associated with hyperplasia and cytokine
4) Confidence 0.20 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.51 Pain Relevance 0.24

General Comments

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