INT201388

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Context Info
Confidence 0.16
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.43
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CPOX) small molecule metabolic process (CPOX) oxidoreductase activity (CPOX)
cytoplasm (CPOX)
Anatomy Link Frequency
SH-SY5Y 1
mesangial cells 1
CPOX (Homo sapiens)
Pain Link Frequency Relevance Heat
intrathecal 2 81.44 Quite High
Spinal cord 24 46.56 Quite Low
antagonist 26 35.96 Quite Low
Inflammation 8 5.00 Very Low Very Low Very Low
allodynia 6 5.00 Very Low Very Low Very Low
Hyperalgesia 6 5.00 Very Low Very Low Very Low
central sensitization 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroblastoma 44 98.68 Very High Very High Very High
Lung Cancer 4 60.80 Quite High
INFLAMMATION 8 5.00 Very Low Very Low Very Low
Hyperalgesia 6 5.00 Very Low Very Low Very Low
Neuropathic Pain 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we observed that ATRA also induces ERK1/2 phosphorylation in SH-SY5Y human neuroblastoma cells (Figure 2c, right) and we confirmed the key role of ERK1/2 phosphorylation for COX-2 up-regulation by ATRA since treatment with PD098059, the selective inhibitor of mitogen-activated protein kinase kinase 1 (MEK-1), was sufficient to abrogate COX-2 promoter activation, to increase COX-2 protein expression and to increase PGE2 production (Figure 2d and Figure 3a right and 3b).
Phosphorylation (phosphorylation) of COX in SH-SY5Y associated with neuroblastoma
1) Confidence 0.16 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1769480 Disease Relevance 0.22 Pain Relevance 0
We have proposed that such mechanism could also be responsible for ATRA-induced COX-2 up-regulation through ERK1/2 phosphorylation in rat mesangial cells [24].
Phosphorylation (phosphorylation) of COX in mesangial cells
2) Confidence 0.11 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1769480 Disease Relevance 0.22 Pain Relevance 0.04

General Comments

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