INT201389

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Context Info
Confidence 0.27
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.58
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RARS) mitochondrion (RARS) nucleolus (RARS)
nucleus (RARS) ligase activity (RARS) cytoplasm (RARS)
RARS (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 34 94.88 High High
Spinal cord 12 89.56 High High
Inflammation 11 78.28 Quite High
central sensitization 1 57.48 Quite High
allodynia 3 26.24 Quite Low
Hyperalgesia 3 25.12 Quite Low
antagonist 15 5.00 Very Low Very Low Very Low
cINOD 7 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 26 97.84 Very High Very High Very High
Osteogenic Sarcomas 79 96.12 Very High Very High Very High
Breast Cancer 45 96.04 Very High Very High Very High
Thyroid Neoplasm 1 92.12 High High
Metastasis 13 91.00 High High
Recurrence 5 88.04 High High
Cancer 59 87.68 High High
INFLAMMATION 16 78.28 Quite High
Non-small-cell Lung Cancer 3 72.84 Quite High
Acute Promyelocytic Leukemia 1 61.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Physiological retinoids are characterized by their capacity to bind and activate retinoid nuclear receptors, including retinoic acid receptors (RARs) and/or retinoid X receptors (RXRs), each having three isotypes, ?
Positive_regulation (activate) of RARs
1) Confidence 0.27 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1769480 Disease Relevance 0.07 Pain Relevance 0.26
Regardless, activated RARs have been observed to exert anti-estrogenic effects by directly or indirectly impairing binding of ER to estrogen response elements (EREs) [31].
Positive_regulation (activated) of RARs
2) Confidence 0.26 Published 2010 Journal Breast Cancer Res Section Body Doc Link PMC2949655 Disease Relevance 0.89 Pain Relevance 0
RARs are activated by all-trans retinoic acid, a vitamin A metabolite, and heterodimerizes with RXR after ligand binding.
Positive_regulation (activated) of RARs
3) Confidence 0.18 Published 2010 Journal PPAR Research Section Body Doc Link PMC2825651 Disease Relevance 1.62 Pain Relevance 0.12

General Comments

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