INT201453

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Context Info
Confidence 0.95
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 4.25
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Hmox1) enzyme binding (Hmox1) signal transducer activity (Hmox1)
cytosol (Hmox1) signal transduction (Hmox1) cell death (Hmox1)
Hmox1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 52 96.36 Very High Very High Very High
withdrawal 8 83.20 Quite High
ischemia 21 57.44 Quite High
Inflammatory mediators 5 45.12 Quite Low
cytokine 12 39.52 Quite Low
Inflammatory response 12 25.00 Low Low
cva 11 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 23 99.46 Very High Very High Very High
Apoptosis 290 97.36 Very High Very High Very High
INFLAMMATION 68 96.36 Very High Very High Very High
Injury 127 94.52 High High
Infection 49 90.84 High High
Hypothermia 4 87.48 High High
Fever 5 83.28 Quite High
Lung Injury 2 73.92 Quite High
Endotoxemia 1 72.88 Quite High
Shock 3 70.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In accordance with the increasing number of studies about HOs, a new paradigm has been emerging that CO, one of byproducts through heme degradation by HO, functions as a signaling molecule that exerts significant cytoprotection due to its anti-inflammatory, vasodilating, and anti-apoptotic properties [82–84].
Protein_catabolism (degradation) of HO associated with inflammation and apoptosis
1) Confidence 0.95 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266059 Disease Relevance 1.54 Pain Relevance 0.15
The stress protein heme oxygenase-1 (HO-1) catalyzes heme degradation producing biliverdin, iron and CO.
Protein_catabolism (degradation) of HO-1 associated with stress
2) Confidence 0.37 Published 2006 Journal BMC Cancer Section Abstract Doc Link PMC1769509 Disease Relevance 0.47 Pain Relevance 0.08
Inside the cytosol, heme is degraded by haem oxygenase 1 (HO-1) which causes the release of iron inside the cell.
Protein_catabolism (degraded) of HO-1
3) Confidence 0.15 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2995786 Disease Relevance 1.12 Pain Relevance 0
Inside the cytosol, heme is degraded by haem oxygenase 1 (HO-1) which causes the release of iron inside the cell.
Protein_catabolism (degraded) of haem oxygenase 1
4) Confidence 0.15 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2995786 Disease Relevance 1.12 Pain Relevance 0

General Comments

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