INT201456

Context Info Confidence 0.06 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.74 Pain Relevance 0.08

cell death (Hmox1, Bcl2) nucleus (Hmox1, Bcl2) endoplasmic reticulum (Hmox1, Bcl2) cytosol (Hmox1, Bcl2) mitochondrion (Bcl2) growth (Bcl2)

Hmox1 (Mus musculus) Bcl2 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 11 87.64 Inflammatory response 2 65.92 withdrawal 8 50.00 anesthesia 1 5.00 ischemia 1 5.00

Disease Link Frequency Relevance Heat Hepatocellular Cancer 22 96.80 Apoptosis 16 91.80 INFLAMMATION 13 87.64 Necrosis 6 69.92 Stress 7 63.60 Cancer 7 33.48 Death 3 15.12 Injury 5 5.00 Hepatitis C Virus Infection 2 5.00 Poisoning 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The mechanism by which HO-1 induces over expression of Bcl-2 is yet unclear.

HO-1 Positive_regulation (induces) of Gene_expression (expression) of Bcl-2

1) Confidence 0.06 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1769509 Disease Relevance 0.74 Pain Relevance 0.08

General Comments

This test has worked.