INT201460

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Context Info
Confidence 0.52
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 2.80
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CDK2) nucleoplasm (CDK2) cytoplasm (CDK2)
cytosol (CDK2) mitosis (CDK2) nucleus (CDK2)
Anatomy Link Frequency
HT-29 6
telomere 2
CDK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 17 99.28 Very High Very High Very High
Spinal cord 12 11.08 Low Low
Inflammation 28 5.00 Very Low Very Low Very Low
Kinase C 13 5.00 Very Low Very Low Very Low
rheumatoid arthritis 6 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Action potential 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bullous Skin Disease 304 99.86 Very High Very High Very High
Acantholysis 65 99.12 Very High Very High Very High
Hepatocellular Cancer 44 98.16 Very High Very High Very High
Apoptosis 121 89.16 High High
Death 28 80.68 Quite High
Aging 8 77.16 Quite High
Hypoxia 35 74.68 Quite High
Colon Cancer 75 64.72 Quite High
Cancer 95 50.00 Quite Low
Adhesions 51 27.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment of HT-29 cells with 5-FU resulted in decreased expressions of p21Cip1 and p27Kip1, and simultaneously in increased expression of CDK2.
Positive_regulation (increased) of Gene_expression (expression) of CDK2 in HT-29
1) Confidence 0.52 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2914703 Disease Relevance 0 Pain Relevance 0
Treatment of HT-29 cells with 5-FU alone resulted in decreased expression of p21Cip1 and p27Kip1, and simultaneously in increased expression of CDK2, as detected by Western blot.
Positive_regulation (increased) of Gene_expression (expression) of CDK2 in HT-29
2) Confidence 0.35 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2914703 Disease Relevance 0.12 Pain Relevance 0
Treatment of HT-29 cells with 5-FU alone resulted in decreased expression of p21Cip1 and p27Kip1, and simultaneously in increased expression of CDK2, as detected by Western blot.
Positive_regulation (resulted) of Gene_expression (expression) of CDK2 in HT-29
3) Confidence 0.35 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2914703 Disease Relevance 0.12 Pain Relevance 0
CDK2 expression increased in HR (49%, P < 0.05) respect to control and HC groups, while no variation was detected in CDK4 in any of the tested groups (Fig. 2).
Positive_regulation (increased) of Gene_expression (expression) of CDK2 associated with hepatocellular cancer
4) Confidence 0.27 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1769509 Disease Relevance 0.28 Pain Relevance 0.04
Cyclin E and CDK2 protein levels are increased after carcinogen withdrawal
Positive_regulation (increased) of Gene_expression (levels) of CDK2 associated with withdrawal
5) Confidence 0.20 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1769509 Disease Relevance 0.19 Pain Relevance 0.05
Low oxygen/DHP-d was determined to exert prominent effects on the overexpression of a variety of proliferation-associated genes, including RUNX3, CDK2, Cyclin D2, CDK1, and telomere reverse transcriptase (TERT; Figure 1E).
Positive_regulation (overexpression) of Gene_expression (overexpression) of CDK2 in telomere
6) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2817727 Disease Relevance 0.58 Pain Relevance 0
PV serum increased protein levels of cdk2 and PV serum-induced acantholysis in vivo was abolished by pharmacologic inhibition of cdk2.
Positive_regulation (increased) of Gene_expression (levels) of cdk2 associated with acantholysis and bullous skin disease
7) Confidence 0.12 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.52 Pain Relevance 0

General Comments

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