INT201462

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Context Info
Confidence 0.39
First Reported 2006
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 5.20
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CDK2) nucleoplasm (CDK2) cytoplasm (CDK2)
cytosol (CDK2) mitosis (CDK2) nucleus (CDK2)
Anatomy Link Frequency
HL-60 1
CDK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 8 65.56 Quite High
agonist 12 58.24 Quite High
narcan 36 20.04 Low Low
antagonist 20 11.64 Low Low
Opioid 52 11.20 Low Low
Inflammation 19 5.36 Low Low
opioid receptor 32 5.00 Very Low Very Low Very Low
Enkephalin 8 5.00 Very Low Very Low Very Low
long-term potentiation 7 5.00 Very Low Very Low Very Low
fibrosis 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 276 99.62 Very High Very High Very High
Retinoblastoma 106 94.28 High High
Disease 25 90.40 High High
Hepatocellular Cancer 48 89.36 High High
Apoptosis 87 87.60 High High
Solid Tumor 2 87.16 High High
Aging 6 86.72 High High
Leukemia 4 86.48 High High
Pancreatic Cancer 165 85.68 High High
Breast Cancer 124 84.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This reduction in Cdk2 kinase activity correlated with an increase in Cdk2/p21 complex formation in the OGF-exposed cells relative to control cultures at all time points.
Cdk2 Binding (formation) of
1) Confidence 0.39 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.87 Pain Relevance 0
OGF does not affect the cyclin E/Cdk2 complex
Cdk2 Neg (not) Binding (complex) of
2) Confidence 0.30 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.12 Pain Relevance 0
OGF reduces Cdk2 kinase activity
Cdk2 Binding (activity) of
3) Confidence 0.30 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.71 Pain Relevance 0
Thus, OGF exerts its effects in these cancer cells by inducing Cdk2/p21 complexes.
Cdk2 Binding (complexes) of associated with cancer
4) Confidence 0.30 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.81 Pain Relevance 0
Hence we need to group the genes CDK2, CYCE together as one cluster, and the ORC genes as another.
CDK2 Binding (group) of
5) Confidence 0.28 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC2944280 Disease Relevance 0 Pain Relevance 0
Based on our understanding of the mechanisms of DMSO and ATRA signaling in HL-60 cells, we know that the point at which these pathways converge is at the G1-S phase transition point controlled by the cyclin dependent kinase complex of Cyclin E and CDK2.
CDK2 Binding (complex) of in HL-60
6) Confidence 0.23 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2791157 Disease Relevance 0.21 Pain Relevance 0
All together these results implicated cyclin E and its associated CDK (CDK2) in the regenerative process.
CDK2 Binding (associated) of
7) Confidence 0.19 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1769509 Disease Relevance 0.61 Pain Relevance 0.03
The cyclin E gene is a target of E2Fs and the protein associates with Cdk2 and activates its kinase activity shortly before entry of cells into the S phase113,115,129 (Fig. 1).
Cdk2 Binding (associates) of
8) Confidence 0.18 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.55 Pain Relevance 0
We observed a decrease in phosphorylation of PI3K, AKT and FOXO3a (Ser318) (Fig. 4A) protein along with decreased activity of Cdk2 (Fig. 3B) with the RNAi treatments.
Cdk2 Binding (activity) of
9) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.24 Pain Relevance 0
Apart from the cyclinE-Cdk2 complex formation, the treatments also decreased the expression of cyclin D1, p21, cyclin D2 and Ki67, which is an indicator of cell proliferation (Fig. 3A).
Cdk2 Binding (formation) of
10) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0 Pain Relevance 0
It is a repressor complex that is formed by cyclins and kinases, cyclin E-Cdk2, and cyclin A-Cdk2 whose constitutive activity is responsible for the deregulation of the cell cycle of tumor cells.
A-Cdk2 Binding (formed) of associated with cancer
11) Confidence 0.08 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2964042 Disease Relevance 1.03 Pain Relevance 0
shown to bind to the Cyclin-dependent kinase CDK2, thus inhibiting its activation.
Cyclin-dependent kinase CDK2 Binding (bind) of
12) Confidence 0.01 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396389 Disease Relevance 0.06 Pain Relevance 0.09

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