INT201463

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.39
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 3.31
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CCNE2) nucleoplasm (CCNE2) nucleus (CCNE2)
cell division (CCNE2)
Anatomy Link Frequency
H69 1
CCNE2 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 275 99.76 Very High Very High Very High
withdrawal 8 66.68 Quite High
Bioavailability 1 51.28 Quite High
Inflammation 48 38.04 Quite Low
alcohol 31 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Dismenorea 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Small Cell Lung Cancer 126 99.34 Very High Very High Very High
Apoptosis 118 98.28 Very High Very High Very High
Hepatocellular Cancer 31 90.48 High High
Cancer 371 88.76 High High
Multiple Myeloma 2 87.00 High High
Aging 1 84.40 Quite High
Glioma 54 78.88 Quite High
Adhesions 9 77.28 Quite High
Adenocarcinoma 7 76.92 Quite High
Retinoblastoma 2 76.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genes, whose products are involved in the transition from G1 to S-phase appeared to be downregulated, such as cyclins (CCNA2, CCNE2, CCNF), cyclin-dependent kinase 2 (CDK2) and transcription regulators (E2F2, PCNA, SKP2), whereas transcription of inhibitory genes cyclin G2 (CCNG2), GADD45A (growth arrest and DNA-damage-inducible, alpha) and p21cip1 (cyclin-dependent kinase inhibitor 1A, CDKN1A) was increased.
Negative_regulation (downregulated) of CCNE2
1) Confidence 0.39 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.11 Pain Relevance 0
In contrast, the treatment with the aglycon mixture caused a marginally stronger up- or downregulation of some genes, such as CCNE2, DNAJB9, E2F2, ESR1 and GADD45A.
Negative_regulation (downregulation) of CCNE2
2) Confidence 0.39 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.23 Pain Relevance 0
The treatment of H69 human SCLC cells with capsaicin leads to a switch in E2F subtypes on cyclin E, TS, cdc25A and cdc6 promoters; E2F1–3 are dissociated from the promoter, and E2F4 and p130 are recruited.
Negative_regulation (switch) of cyclin E in H69 associated with qutenza and small cell lung cancer
3) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.71 Pain Relevance 0.39
All together these results implicated cyclin E and its associated CDK (CDK2) in the regenerative process.
Negative_regulation (implicated) of cyclin E
4) Confidence 0.04 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1769509 Disease Relevance 0.55 Pain Relevance 0.03
The results revealed little or no expression of cyclin E in pU, pC and pCU treated cell lysates compared to control and SV transfected cells indicating that the treatments reduced the cyclinE-Cdk2 complex formation. pCU-treated cells showed significant downregulation of cyclin E as compared to pU and pC treatments.
Negative_regulation (downregulation) of cyclin E
5) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0 Pain Relevance 0
We found that the anti-proliferative activity of capsaicin is correlated with a decrease in the expression of E2F-responsive proliferative genes like cyclin E, thymidylate synthase, cdc25A and cdc6, both at mRNA and protein levels.
Negative_regulation (decrease) of cyclin E associated with qutenza
6) Confidence 0.02 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2857654 Disease Relevance 0.67 Pain Relevance 0.91
Therefore, the G0/G1 arrest induced by the treatments could be due to the combined action of reduced cyclin D1, cyclin D2, and cyclin E-Cdk2 complex formation and increased expression of p27Kip1.
Negative_regulation (reduced) of cyclin E
7) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.30 Pain Relevance 0
The growth-inhibitory effects of resveratrol are mediated through cell-cycle arrest; induction of apoptosis via Fas/CD95, p53, ceramide activation, tubulin polymerization, mitochondrial and adenylyl cyclase pathways; up-regulation of p21 p53 and Bax; down-regulation of survivin, cyclin D1, cyclin E, Bcl-2, Bcl-xL, and cellular inhibitor of apoptosis proteins; activation of caspases; suppression of nitric oxide synthase; suppression of transcription factors such as NF-?
Negative_regulation (regulation) of cyclin E associated with apoptosis
8) Confidence 0.01 Published 2008 Journal Pharm Res Section Body Doc Link PMC2515569 Disease Relevance 0.75 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox