INT201465

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Context Info
Confidence 0.13
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.13
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CCNE2) nucleoplasm (CCNE2) nucleus (CCNE2)
cell division (CCNE2)
Anatomy Link Frequency
lymph node 1
H69 1
CCNE2 (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 16 99.28 Very High Very High Very High
qutenza 260 98.88 Very High Very High Very High
Inflammation 36 95.20 Very High Very High Very High
Pain 3 17.60 Low Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 251 99.54 Very High Very High Very High
Death 19 99.12 Very High Very High Very High
Cancer 306 98.56 Very High Very High Very High
Small Cell Lung Cancer 126 97.56 Very High Very High Very High
INFLAMMATION 34 95.20 Very High Very High Very High
Metastasis 25 94.44 High High
Genomic Instability 6 89.72 High High
Malignant Neoplastic Disease 16 85.68 High High
Hepatocellular Cancer 44 77.36 Quite High
Apoptosis 76 76.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cyclin E is expressed in supra-physiological levels in many human cancers and its genomic locus (19q12-q13) is frequently amplified.161,162 High levels of cyclin E and low levels of the G1-specific cell cycle inhibitor p27KIP1 exhibit a good correlation.159,163–169 Another clue for the importance of cyclin E in breast carcinoma is the finding of centrosome amplifications in these tumors, which could pave the way for genomic instability.170–172
Positive_regulation (levels) of cyclin E associated with genomic instability, cancer and breast cancer
1) Confidence 0.13 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.60 Pain Relevance 0
In fact, the hazard ratio for death due to breast cancer in patients with high levels of cyclin E was higher than associated with any other biological marker examined (seven times higher than the hazard ratio associated with lymph node metastases).
Positive_regulation (levels) of cyclin E in lymph node associated with breast cancer, metastasis and death
2) Confidence 0.13 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.92 Pain Relevance 0
E2F1, E2F2 and E2F3 are often referred to as “activator” E2Fs because they transcriptionally activate E2F target proliferative genes such as cyclin E, cdc25A and cdc6 [25], [27], [28], [29].
Positive_regulation (activate) of cyclin E
3) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.24 Pain Relevance 0.34
During G1 phase, the D-type cyclins (generally cyclin D1) are expressed in response to mitogenic signals, and by binding to CDK4 and CDK6, lead to activation of cyclin E/CDK2 and cyclin A/CDK2 in late G1 and S phase.
Positive_regulation (activation) of cyclin E
4) Confidence 0.08 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2914703 Disease Relevance 0.12 Pain Relevance 0
Therefore, ChIP assays were performed to examine the differential occupancy of E2F family of proteins on E2F-responsive proliferative promoters (cyclin E, TS, cdc25A and cdc6) upon capsaicin-treatment of H69 human SCLC cells [31], [32], [40], [45].
Spec (examine) Positive_regulation (occupancy) of cyclin E in H69 associated with qutenza and small cell lung cancer
5) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.27 Pain Relevance 0.49
Cyclin E and CDK2 protein levels are increased after carcinogen withdrawal
Positive_regulation (increased) of Cyclin E associated with withdrawal
6) Confidence 0.04 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1769509 Disease Relevance 0.19 Pain Relevance 0.05
We reported here a striking increase in CDK2 and cyclin E expression in HR animals.
Positive_regulation (increase) of cyclin E
7) Confidence 0.02 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1769509 Disease Relevance 0.78 Pain Relevance 0.05

General Comments

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