INT201467

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Context Info
Confidence 0.77
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.83
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (HMOX1) endoplasmic reticulum (HMOX1) enzyme binding (HMOX1)
transmembrane transport (HMOX1) signal transducer activity (HMOX1) cytosol (HMOX1)
Anatomy Link Frequency
monocytes 1
HMOX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 8 83.20 Quite High
Infliximab 2 60.72 Quite High
Inflammatory response 9 50.28 Quite High
Inflammation 27 5.00 Very Low Very Low Very Low
rheumatoid arthritis 10 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 8 99.82 Very High Very High Very High
Apoptosis 16 98.08 Very High Very High Very High
Injury 5 91.76 High High
Disease 79 83.84 Quite High
Hepatocellular Cancer 22 62.64 Quite High
Poisoning 2 59.12 Quite High
INFLAMMATION 37 49.92 Quite Low
Necrosis 8 25.00 Low Low
Rheumatoid Arthritis 10 5.00 Very Low Very Low Very Low
Cancer 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our previous study [26] we demonstrated that TNF enhances HO-1 mRNA degradation, resulting in a reduction in HO-1 expression in human monocytes.
Protein_catabolism (degradation) of HO-1 mRNA in monocytes
1) Confidence 0.77 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.36 Pain Relevance 0.06
The stress protein heme oxygenase-1 (HO-1) catalyzes heme degradation producing biliverdin, iron and CO.
Protein_catabolism (degradation) of heme oxygenase-1 associated with stress
2) Confidence 0.17 Published 2006 Journal BMC Cancer Section Abstract Doc Link PMC1769509 Disease Relevance 0.47 Pain Relevance 0.08

General Comments

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