INT201468

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Context Info
Confidence 0.17
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.10
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CDK2) nucleoplasm (CDK2) cytoplasm (CDK2)
cytosol (CDK2) mitosis (CDK2) nucleus (CDK2)
CDK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 8 66.68 Quite High
Inflammation 11 5.36 Low Low
cINOD 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 22 90.48 High High
Apoptosis 34 87.60 High High
Aging 1 86.72 High High
Glioma 52 80.00 Quite High
Cancer 77 58.12 Quite High
Death 3 51.04 Quite High
Retinoblastoma 2 18.56 Low Low
INFLAMMATION 15 5.36 Low Low
Stress 7 5.00 Very Low Very Low Very Low
Necrosis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We observed a decrease in phosphorylation of PI3K, AKT and FOXO3a (Ser318) (Fig. 4A) protein along with decreased activity of Cdk2 (Fig. 3B) with the RNAi treatments.
Negative_regulation (decreased) of Cdk2 Binding (activity) of
1) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.24 Pain Relevance 0
We observed a decrease in phosphorylation of PI3K, AKT and FOXO3a (Ser318) (Fig. 4A) protein along with decreased activity of Cdk2 (Fig. 3B) with the RNAi treatments.
Negative_regulation (decrease) of Cdk2 Binding (activity) of
2) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.25 Pain Relevance 0
All together these results implicated cyclin E and its associated CDK (CDK2) in the regenerative process.
Negative_regulation (implicated) of CDK2 Binding (associated) of
3) Confidence 0.17 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1769509 Disease Relevance 0.61 Pain Relevance 0.03

General Comments

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