INT201475

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.74
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Ednrb) aging (Ednrb) plasma membrane (Ednrb)
signal transducer activity (Ednrb)
Anatomy Link Frequency
middle cerebral artery 2
Ednrb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 125 99.64 Very High Very High Very High
cva 25 93.76 High High
ischemia 65 86.12 High High
agonist 11 45.56 Quite Low
anesthesia 6 37.60 Quite Low
halothane 12 34.88 Quite Low
withdrawal 6 5.00 Very Low Very Low Very Low
Intracerebroventricular 1 5.00 Very Low Very Low Very Low
Serotonin 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infarction 45 100.00 Very High Very High Very High
Stroke 26 99.98 Very High Very High Very High
Middle Cerebral Artery Infarction 102 98.76 Very High Very High Very High
Cv General 3 Under Development 3 93.76 High High
Cv General 4 Under Development 80 91.16 High High
Disease 5 83.40 Quite High
Cv Unclassified Under Development 11 71.16 Quite High
Myocardial Infarction 5 52.40 Quite High
Cardiovascular Disease 5 51.08 Quite High
Brain Hemorrhage 5 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with the PKC inhibitor Ro-32-0432 reduces the upregulation of ETB receptors in the ipsilateral MCA 24 hours after transient middle cerebral artery occlusion.
Negative_regulation (reduces) of Positive_regulation (upregulation) of ETB in middle cerebral artery associated with kinase c and middle cerebral artery infarction
1) Confidence 0.42 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1770924 Disease Relevance 0.65 Pain Relevance 0.41
This is also seen in organ culture, where the upregulation of contractile ETB receptors in MCA is attenuated by both PKC inhibitors and ERK1/2 inhibitors [13,14,29].
Negative_regulation (attenuated) of Positive_regulation (upregulation) of ETB associated with kinase c
2) Confidence 0.42 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1770924 Disease Relevance 0.62 Pain Relevance 0.39
Furthermore, the contractile ETB receptor upregulation seen in the ipsilateral MCA of the control animals is attenuated by the Ro-32-0432 treatment.
Negative_regulation (attenuated) of Positive_regulation (upregulation) of ETB receptor
3) Confidence 0.33 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1770924 Disease Relevance 0.60 Pain Relevance 0.39
The Ro-32-0432 treatment decreased the ETB receptor upregulation, as well as diminished the ischemic infarct area and improved the neurological status of the animals.
Negative_regulation (decreased) of Positive_regulation (upregulation) of ETB receptor
4) Confidence 0.33 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1770924 Disease Relevance 0.90 Pain Relevance 0.22
The results suggest that treatment with Ro-32-0432 in ischemic stroke decreases the ischemic infarction area, neurological symptoms and associated endothelin B receptor upregulation.
Negative_regulation (decreases) of Positive_regulation (upregulation) of endothelin B receptor associated with stroke and infarction
5) Confidence 0.33 Published 2007 Journal BMC Neurosci Section Abstract Doc Link PMC1770924 Disease Relevance 0.60 Pain Relevance 0.19
Treatment with the MEK inhibitor (U0126) given in conjunction with reperfusion (0 hour) prevented the increase in the ETB receptor protein (101 ± 5%) (Fig. 9).


Negative_regulation (prevented) of Positive_regulation (increase) of ETB receptor protein
6) Confidence 0.16 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2553085 Disease Relevance 0.37 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox