INT201497

Context Info Confidence 0.27 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 1.70 Pain Relevance 1.00

peptidase activity (Prss2) extracellular space (Prss2) extracellular region (Prss2)

Prss2 (Mus musculus)

Pain Link Frequency Relevance Heat fibrosis 13 98.44 Chronic pancreatitis 96 94.84 Bile 6 79.96 abdominal pain 2 75.08 Pain management 3 68.40 Inflammation 6 5.00 Pain 6 5.00 alcohol 3 5.00 imagery 3 5.00 Lasting pain 1 5.00

Disease Link Frequency Relevance Heat Cystic Fibrosis 12 98.72 Pancreatitis 123 94.84 Disease 24 84.28 Pancreatic Cancer 16 82.36 Duodenal Obstruction 4 81.16 Diabetes Mellitus 8 79.20 Vomiting 4 78.24 Abdominal Pain 2 75.08 Pain 9 68.40 Targeted Disruption 9 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Other genes, such as the anionic trypsinogen (PRSS2), the serine protease inhibitor, Kazal type 1 (SPINK1) and the cystic fibrosis transmembrane conductance regulator (CFTR) have been found to be associated with chronic pancreatitis (idiopathic and hereditary) as well.

Negative_regulation (inhibitor) of Positive_regulation (anionic) of PRSS2 associated with fibrosis, cystic fibrosis and chronic pancreatitis

1) Confidence 0.27 Published 2007 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC1774562 Disease Relevance 1.70 Pain Relevance 1.00

General Comments

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