INT201509

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Context Info
Confidence 0.61
First Reported 2007
Last Reported 2007
Negated 3
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.20
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PRSS1) extracellular space (PRSS1) extracellular region (PRSS1)
Anatomy Link Frequency
pancreas 2
PRSS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 384 89.44 High High
fibrosis 52 5.00 Very Low Very Low Very Low
Inflammation 24 5.00 Very Low Very Low Very Low
Pain 24 5.00 Very Low Very Low Very Low
Bile 24 5.00 Very Low Very Low Very Low
Pain management 12 5.00 Very Low Very Low Very Low
alcohol 12 5.00 Very Low Very Low Very Low
imagery 12 5.00 Very Low Very Low Very Low
abdominal pain 8 5.00 Very Low Very Low Very Low
Lasting pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 492 98.56 Very High Very High Very High
Autolysis 4 76.80 Quite High
Targeted Disruption 36 41.04 Quite Low
Disease 96 25.44 Quite Low
Pancreatic Cancer 64 5.00 Very Low Very Low Very Low
Cystic Fibrosis 48 5.00 Very Low Very Low Very Low
Pain 36 5.00 Very Low Very Low Very Low
Diabetes Mellitus 32 5.00 Very Low Very Low Very Low
Calcification 20 5.00 Very Low Very Low Very Low
INFLAMMATION 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Biochemical characterization of the N29I mutation using recombinant trypsinogen found no effect on trypsin or trypsinogen stability.
Neg (no) Regulation (effect) of Protein_catabolism (stability) of trypsin
1) Confidence 0.61 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.20 Pain Relevance 0
Biochemical characterization of the N29I mutation using recombinant trypsinogen found no effect on trypsin or trypsinogen stability.
Neg (no) Regulation (effect) of Protein_catabolism (stability) of trypsinogen
2) Confidence 0.44 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.20 Pain Relevance 0
David Whitcomb proposed that the Arg122-Val123 autolytic peptide bond in trypsin plays an important role in the degradation of prematurely activated trypsin in the pancreas.
Regulation (role) of Protein_catabolism (degradation) of trypsin in pancreas
3) Confidence 0.27 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.59 Pain Relevance 0.14
More importantly, the model fails to explain how the other pancreatitis associated PRSS1 mutations might work, as the majority of these do not affect trypsin stability.


Neg (not) Regulation (affect) of Protein_catabolism (stability) of trypsin associated with pancreatitis
4) Confidence 0.27 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.21 Pain Relevance 0

General Comments

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