INT201524

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Context Info
Confidence 0.62
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 9.24
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Wnt2) molecular_function (Wnt2) cell-cell signaling (Wnt2)
cytoplasm (Wnt2)
Anatomy Link Frequency
plasma 1
MCF7 1
osteoblast 1
B cell 1
heart 1
Wnt2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 37 99.96 Very High Very High Very High
Nicotine 6 89.76 High High
metalloproteinase 4 80.12 Quite High
Potency 6 70.88 Quite High
Dopamine 31 67.04 Quite High
Central nervous system 15 56.56 Quite High
cINOD 18 51.36 Quite High
Ventral tegmentum 1 48.52 Quite Low
cytokine 4 44.60 Quite Low
Inflammation 11 43.04 Quite Low
Disease Link Frequency Relevance Heat
Multiple Myeloma 21 99.98 Very High Very High Very High
Apoptosis 67 99.74 Very High Very High Very High
Cancer 247 99.20 Very High Very High Very High
Hematologic Neoplasms 33 99.04 Very High Very High Very High
Injury 33 98.44 Very High Very High Very High
Osteoporosis 54 97.96 Very High Very High Very High
Carcinoma 58 95.84 Very High Very High Very High
Nasopharynx Cancer 145 93.60 High High
Targeted Disruption 27 92.64 High High
Hepatocellular Cancer 6 90.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
7-nAChR could be a target of the Wnt pathway by regulating the pre-synaptic localization of APC and ?
Localization (localization) of Wnt
1) Confidence 0.62 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.12 Pain Relevance 0.11
As discussed by Baranski et al (2000) [64] it is also possible that sFRPs operate agonistically to Wnt signaling in some circumstances: for example, sFRP2 (SARP-1) increases resistance of MCF7 breast adeno-carcinoma cells to apoptotic signals, whereas sFRP1 (SARP-2) sensitizes the same cell [63] via opposing effects on intracellular ?
Localization (operate) of Wnt in MCF7 associated with carcinoma and apoptosis
2) Confidence 0.62 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 1.06 Pain Relevance 0
Wnt secretion is controlled by the Wntless/evenness transmembrane protein [58].
Localization (secretion) of Wnt
3) Confidence 0.16 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 0.36 Pain Relevance 0
Wnt signaling pathways are categorized as "canonical "and "non-canonical" Wnt pathways, which are ?
Localization (categorized) of Wnt
4) Confidence 0.09 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2954871 Disease Relevance 0.97 Pain Relevance 0
-catenin in hematopoietic stem cells blocks multilineage differentiation; including B cell differentiation at early stages, suggesting the importance of fine tuning of Wnt/?
Localization (tuning) of Wnt in B cell
5) Confidence 0.09 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2954871 Disease Relevance 0.48 Pain Relevance 0
Besides these mutations in intracellular signaling components, several tumors display a missing of expression of the secreted Wnt antagonists sFRPs and WIF1 resulting from silencing by promoter hypermethylation [15].
Localization (secreted) of Wnt associated with cancer and antagonist
6) Confidence 0.09 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2954871 Disease Relevance 1.30 Pain Relevance 0.14
In our study, cell-specific Wnt signaling and its localization was visualized in response to cardiac injury using Axin2+/LacZ reporter mice.
Localization (localization) of Wnt associated with injury
7) Confidence 0.05 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916122 Disease Relevance 0.47 Pain Relevance 0.04
To localize active Wnt signaling in the injured heart, we analyzed ?
Localization (localize) of Wnt in heart
8) Confidence 0.05 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916122 Disease Relevance 0.47 Pain Relevance 0
Wnt proteins form a family of highly conserved secreted signaling molecules in which the canonical Wnt/?
Localization (secreted) of Wnt
9) Confidence 0.04 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916122 Disease Relevance 0.44 Pain Relevance 0
In a seminal study it has been demonstrated that in MM secretion of the Wnt antagonist Dkk-1 by the neoplastic cells inhibits osteoblast recruitment and activity.
Localization (secretion) of Wnt in osteoblast associated with antagonist, osteoporosis and multiple myeloma
10) Confidence 0.03 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020964 Disease Relevance 1.53 Pain Relevance 0.13
At that time, it was reported to be a secreted protein that inhibited Wnt signal transduction, but did not bind directly to Wnt proteins.
Localization (secreted) of Wnt
11) Confidence 0.02 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.17 Pain Relevance 0
At that time, it was reported to be a secreted protein that inhibited Wnt signal transduction, but did not bind directly to Wnt proteins.
Localization (secreted) of Wnt
12) Confidence 0.02 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.17 Pain Relevance 0
B2 and survivin played central roles in increasing resistance to apoptosis, as well as changes in integrin and Wnt/?
Localization (changes) of Wnt associated with apoptosis
13) Confidence 0.01 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.50 Pain Relevance 0
The PDZ domain-containing protein PICK1, which binds to a type II PDZ binding site localized at the DAT distal carboxyl termini, increases the efficiency of ER-to-plasma membrane trafficking of the transporter [7,16].
Localization (localized) of type II PDZ binding site in plasma
14) Confidence 0.01 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0.18 Pain Relevance 0.03

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