INT201547

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Context Info
Confidence 0.20
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 9
Disease Relevance 2.19
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (ERI3)
Anatomy Link Frequency
nodes 3
ERI3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 6 10.88 Low Low
cINOD 1 10.88 Low Low
Rsd 29 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
positron emission tomography 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nasopharynx Cancer 145 99.64 Very High Very High Very High
Apoptosis 25 99.24 Very High Very High Very High
Cancer 88 97.80 Very High Very High Very High
Death 3 94.88 High High
Disease 11 93.44 High High
Genomic Instability 10 88.32 High High
Aneuploidy 23 83.28 Quite High
Chromosomal Instability 1 61.68 Quite High
Polyploidy 8 57.36 Quite High
Congenital Anomalies 3 18.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Technically, PINT integrates pathways at the level of nodes, which may consist of one or multiple entities (i.e. a complex).
Gene_expression (integrates) of PINT in nodes
1) Confidence 0.20 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2896112 Disease Relevance 0 Pain Relevance 0
PINT provides ?
Gene_expression (provides) of PINT
2) Confidence 0.20 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2896112 Disease Relevance 0 Pain Relevance 0
The BPI conducted by PINT relies on putatively identical nodes (PIN) sets (see section ‘The pathways integration rule’), but not on any gene or protein expression data.
Gene_expression (conducted) of PINT in nodes
3) Confidence 0.20 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2896112 Disease Relevance 0 Pain Relevance 0
Therefore, PINT provides a ‘painting’ function that can highlight entities based on users' gene-symbol lists (for the sample format see Supplementary Figure S11), expression data or the tissue/histology information (Supplementary Figure S5, S8–S10) retrieved from UniGene (http://www.ncbi.nlm.nih.gov/unigene).
Gene_expression (expression) of PINT
4) Confidence 0.20 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2896112 Disease Relevance 0.06 Pain Relevance 0
The PINT public models and users' private models
Gene_expression (models) of PINT
5) Confidence 0.20 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2896112 Disease Relevance 0 Pain Relevance 0
For integrating pathways P1 and P2, as in Figure 1A, PINT uses the following criteria to determine if nodes N1 and N2 can be linkers:
Gene_expression (uses) of PINT in nodes
6) Confidence 0.20 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2896112 Disease Relevance 0 Pain Relevance 0
C. elegans has at least two types of these nucleases, which belong to the Eri-1/3'hExo and Pint1 subclassses, respectively.
Gene_expression (subclassses) of Pint1
7) Confidence 0.10 Published 2008 Journal Genome Biol Section Body Doc Link PMC2395250 Disease Relevance 0.09 Pain Relevance 0
Knockdown of bcl-xL expression with RNAi induced NPC cells apoptosis, suggesting that the siRNA technique could provide a new method for anti-NPC gene therapy [34].
Gene_expression (expression) of RNAi associated with nasopharynx cancer and apoptosis
8) Confidence 0.01 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.33 Pain Relevance 0
Evidence supporting this mechanism is that expression of dominant negative forms of ECT2, and RNAi knockdown of ECT2 protein, impair microtubule attachment to kinetochores and cause prometaphase delay and abnormal chromosomal segregation [31].
Gene_expression (expression) of RNAi
9) Confidence 0.00 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792351 Disease Relevance 0.71 Pain Relevance 0

General Comments

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