INT20156

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Context Info
Confidence 0.49
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 2.89
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpine1) extracellular region (Serpine1)
Anatomy Link Frequency
plasma 2
endothelial cells 2
vein 2
Serpine1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
b2 receptor 4 90.04 High High
bradykinin 10 89.24 High High
Angina 8 87.44 High High
analgesia 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
epidural 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Dismenorea 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 4 99.98 Very High Very High Very High
Coronary Vasospasm 10 98.48 Very High Very High Very High
Myocardial Infarction 8 94.12 High High
Angina 8 87.44 High High
Coronary Heart Disease 1 80.80 Quite High
Pressure And Volume Under Development 16 73.40 Quite High
Hereditary Angioedema 48 66.24 Quite High
Syndrome 2 55.72 Quite High
Endometriosis (extended) 8 41.44 Quite Low
Reprotox - General 1 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In healthy women taking oral contraception, there is an increase of fibrinolytic proteins: elevation of plasmin, factors VII, X, IX and a decrease of plasminogen activator inhibitor (PAI) [12-14].
Positive_regulation (increase) of Negative_regulation (decrease) of PAI
1) Confidence 0.49 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2918592 Disease Relevance 0.36 Pain Relevance 0.21
Thus, the coronary vasospasm induced the release of t-PA from endothelial cells of coronary vessels and resulted in the reduction in the PAI activity in the great cardiac vein.
Positive_regulation (resulted) of Negative_regulation (reduction) of PAI in endothelial cells associated with coronary vasospasm
2) Confidence 0.11 Published 1990 Journal Jpn. Circ. J. Section Abstract Doc Link 2125083 Disease Relevance 0.70 Pain Relevance 0.19
The maximal dose of ergonovine (0.4 mg) induced mild diffuse coronary vasoconstriction in the controls, and this diffuse coronary vasoconstriction induced a reduction of PAI levels in the great cardiac vein from 11.9 +/- 4.9 IU/ml to 9.5 +/- 4.8 IU/ml (p less than 0.05).
Positive_regulation (induced) of Negative_regulation (reduction) of PAI in vein associated with increased venous pressure under development
3) Confidence 0.11 Published 1990 Journal Jpn. Circ. J. Section Abstract Doc Link 2125083 Disease Relevance 0.82 Pain Relevance 0.23
In healthy women taking oral contraception, there is an increase of fibrinolytic proteins: elevation of plasmin, factors VII, X, IX and a decrease of plasminogen activator inhibitor (PAI) [12-14].
Positive_regulation (increase) of Negative_regulation (decrease) of activator inhibitor
4) Confidence 0.11 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2918592 Disease Relevance 0.36 Pain Relevance 0.21
This reduction was associated with elevation of PAI-I activity and reduction of tPA activity, independent of changes in plasma insulin levels.
Positive_regulation (elevation) of Negative_regulation (elevation) of PAI-I in plasma
5) Confidence 0.04 Published 2002 Journal Endocr. Res. Section Abstract Doc Link 12489566 Disease Relevance 0.64 Pain Relevance 0.12

General Comments

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