INT201570

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Context Info
Confidence 0.48
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 14.21
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CR2)
Anatomy Link Frequency
B-cell 4
testis 1
brain 1
Platelets 1
CR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 43 99.12 Very High Very High Very High
metalloproteinase 16 99.06 Very High Very High Very High
Inflammatory response 4 99.04 Very High Very High Very High
bradykinin 2 11.64 Low Low
imagery 3 10.28 Low Low
headache 5 7.52 Low Low
Multiple sclerosis 82 5.00 Very Low Very Low Very Low
chemokine 35 5.00 Very Low Very Low Very Low
5HT 23 5.00 Very Low Very Low Very Low
Central nervous system 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Epstein-barr Virus 689 100.00 Very High Very High Very High
Nasopharynx Cancer 146 99.84 Very High Very High Very High
Cancer 134 99.76 Very High Very High Very High
Infection 267 99.64 Very High Very High Very High
INFLAMMATION 48 99.12 Very High Very High Very High
Metastasis 15 98.54 Very High Very High Very High
T-cell Lymphoma 120 98.24 Very High Very High Very High
Apoptosis 12 96.90 Very High Very High Very High
Viral Infection 11 90.68 High High
Lymphatic System Cancer 253 89.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, transcripts coding for complement components C1R and C2R are also observed in tissues where antigens are encountered (for example, intestines and lung, but not brain, testis or bone marrow), and the messenger RNAs for inflammatory response mediators such as complement receptors CR1 and CR2, which are expressed on lymphoid cells, are seen at higher levels in spleen, tonsil, and lymph node.
Gene_expression (expressed) of CR2 in brain associated with inflammatory response
1) Confidence 0.48 Published 2006 Journal Genome Biol Section Body Doc Link PMC1794557 Disease Relevance 0.10 Pain Relevance 0.05
Residual CD21 positive, and CD23 positive follicular dentritic cells were also seen (Fig. 5).
Gene_expression (positive) of CD21
2) Confidence 0.30 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1808440 Disease Relevance 0.35 Pain Relevance 0
Platelets possess C receptors CR2, CR3, CR4, C1q, C1-inhibitor, and factors D, and H.
Gene_expression (possess) of CR2 in Platelets
3) Confidence 0.23 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2829540 Disease Relevance 0.41 Pain Relevance 0.08
The tumor cells were immunonegative for CD3, CD5, cyclin D1, CD21, CD23, CD10, and Ig M.
Gene_expression (immunonegative) of CD21 associated with cancer
4) Confidence 0.20 Published 2008 Journal J Hematop Section Body Doc Link PMC2713483 Disease Relevance 0.85 Pain Relevance 0
B-cell tropism of EBV through the EBV-specific receptor CD21 (CR2), which is expressed on B cells and developing T cells but not on mature peripheral T cells, is well known (18).
Gene_expression (expressed) of CR2 in B-cell associated with epstein-barr virus
5) Confidence 0.19 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526432 Disease Relevance 2.37 Pain Relevance 0
B-cell tropism of EBV through the EBV-specific receptor CD21 (CR2), which is expressed on B cells and developing T cells but not on mature peripheral T cells, is well known (18).
Gene_expression (expressed) of EBV-specific receptor CD21 in B-cell associated with epstein-barr virus
6) Confidence 0.19 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526432 Disease Relevance 2.45 Pain Relevance 0
However, transcripts coding for complement components C1R and C2R are also observed in tissues where antigens are encountered (for example, intestines and lung, but not brain, testis or bone marrow), and the messenger RNAs for inflammatory response mediators such as complement receptors CR1 and CR2, which are expressed on lymphoid cells, are seen at higher levels in spleen, tonsil, and lymph node.
Gene_expression (expressed) of CR2 in testis associated with inflammatory response
7) Confidence 0.16 Published 2006 Journal Genome Biol Section Body Doc Link PMC1794557 Disease Relevance 0.10 Pain Relevance 0.05
B-cell tropism of EBV through the EBV-specific receptor CD21 (CR2), which is expressed on B cells and developing T cells but not on mature peripheral T cells, is well known (18).
Gene_expression (expressed) of CR2 in B-cell associated with epstein-barr virus
8) Confidence 0.16 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526432 Disease Relevance 2.37 Pain Relevance 0
B-cell tropism of EBV through the EBV-specific receptor CD21 (CR2), which is expressed on B cells and developing T cells but not on mature peripheral T cells, is well known (18).
Gene_expression (expressed) of EBV-specific receptor CD21 in B-cell associated with epstein-barr virus
9) Confidence 0.16 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526432 Disease Relevance 2.45 Pain Relevance 0
To identify the lytic phase of the EBV infections, we analyzed the expression of the ZEBRA protein (Bam HI Z Epstein-Barr replication activator) [38] by Western blotting applying an anti-ZEBRA monoclonal antibody.
Spec (analyzed) Gene_expression (expression) of Bam HI Z Epstein-Barr replication activator associated with epstein-barr virus and infection
10) Confidence 0.12 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2861168 Disease Relevance 0.72 Pain Relevance 0
Measuring the expression of latent EBV genes in NPC and normal nasopharyngeal tissue samples, it was shown that deregulation of key proteins involving in apoptosis (bcl-2 related protein A1 and Fas apoptotic inhibitory molecule), cell cycle checkpoints (AKIP, SCYL1 and NIN) and metastasis (matrix metalloproteinase 1) were closely correlated with the levels of EBV gene expression in NPC [77].
Gene_expression (expression) of EBV gene associated with nasopharynx cancer, metalloproteinase, epstein-barr virus, apoptosis and metastasis
11) Confidence 0.02 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.75 Pain Relevance 0.05
Proteins that efficiently disrupt PML-NBs (HCMV IE1 and EBV Zta) are expressed within infected cells in vitro prior to the time when the CHPKs are expressed [101], [102], so the ability of the HHV-4 and HHV-5 CHPKs to decrease the numbers of PML-NBs when ectopically expressed may have limited relevance during viral infection.
Gene_expression (expressed) of EBV Zta associated with viral infection and epstein-barr virus
12) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2936540 Disease Relevance 0.27 Pain Relevance 0

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