INT201600

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Context Info
Confidence 0.05
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.35
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
epidermis 2
reticulum 1
Uvbi1 (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 99 90.68 High High
Disease Link Frequency Relevance Heat
Stress 33 96.48 Very High Very High Very High
Hypoxia 6 88.76 High High
Metastasis 33 82.88 Quite High
Skin Cancer 147 82.44 Quite High
Cancer 27 67.76 Quite High
Blister 3 41.60 Quite Low
Apoptosis 18 41.24 Quite Low
Dna Damage 3 28.72 Quite Low
Burns 15 25.00 Low Low
Repression 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We identified melanocyte- and Mc1r-dependent UVB gene expression profiles in the basal epidermis.
Gene_expression (expression) of UVB in epidermis
1) Confidence 0.05 Published 2007 Journal PLoS Genetics Section Abstract Doc Link PMC1774588 Disease Relevance 0.21 Pain Relevance 0.25
From the cDNAs shown to be UVB responsive in the basal epidermis (Figure 1 and Table S1), we identified a nonredundant set of 1,201 UniGene IDs.
Gene_expression (responsive) of UVB in epidermis
2) Confidence 0.05 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.17 Pain Relevance 0
We also identified additional genes, within the Kit-dependent UVB response, that were not annotated in the GO database as oxidative or endoplasmic reticulum (ER) stress response genes, including Cdk5, Eif1, Egln1, Ext1, Gpr175, Gpt2, Itm1, Nars, Pabpc1, Pecam1, Prdx4, Prkrip1, Pten, Rheb, Sh3glb1, Tbc1d20, and Tuba3, for which roles in oxidative stress/hypoxia and the ER stress/unfolded protein response have been reported [73–76].
Gene_expression (response) of UVB in reticulum associated with stress and hypoxia
3) Confidence 0.05 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.97 Pain Relevance 0

General Comments

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