INT201602

Context Info Confidence 0.04 First Reported 2007 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 2 Total Number 3 Disease Relevance 1.17 Pain Relevance 0.04

Uvbi1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 7 71.04 Inflammatory response 2 42.72 melanocortin 1 receptor 66 5.00 headache 1 5.00

Disease Link Frequency Relevance Heat Gastrointestinal Neoplasms 1 88.96 Malignant Neoplastic Disease 4 88.24 Stress 26 84.28 Genomic Instability 11 82.44 Keratosis 4 80.08 Squamous Cell Neoplasms 2 77.60 Death 15 74.40 Apoptosis 29 71.48 INFLAMMATION 9 71.04 Dna Damage 5 67.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Collectively, we refer to the 120 UVB × Mc1r genes as the Mc1r-dependent UVB-responsive genes (Table S4) and the 147 UVB × Kit genes as the Kit-dependent UVB-responsive genes (Table S5).

Positive_regulation (dependent) of UVB

1) Confidence 0.04 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.05 Pain Relevance 0

Post hoc analyses performed separately on each of the 120 and 147 gene sets yielded three patterns, depending on whether a gene responded to UVB only in the mutant, only in the nonmutant, or in both mutant and nonmutant genotypes (Figure 5).

Spec (whether) Positive_regulation (responded) of UVB

2) Confidence 0.04 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.06 Pain Relevance 0

Nicotinamide protected against UV-induced immunosuppression in mice and humans and UV-induced carcinogenesis in mice.

Positive_regulation (induced) of immunosuppression

3) Confidence 0.02 Published 2010 Journal Journal of Nucleic Acids Section Body Doc Link PMC2915624 Disease Relevance 1.06 Pain Relevance 0.04

General Comments

This test has worked.