INT201603

Context Info Confidence 0.05 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.05 Pain Relevance 0

Uvbi1 (Mus musculus)

Pain Link Frequency Relevance Heat melanocortin 1 receptor 33 23.36

Disease Link Frequency Relevance Heat Stress 11 50.72 Skin Cancer 49 20.08 Repression 6 16.00 Metastasis 11 5.00 Cancer 9 5.00 Apoptosis 6 5.00 Burns 5 5.00 Hypersensitivity 5 5.00 Hypoxia 2 5.00 Death 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The Mc1r-dependent UVB response was characterized largely by genes involved in the cell cycle (Cdc2l1, Fos, Hspa8, Mtcp1, Top3a, and 2810406C15Rik) and oncogenesis (Cdc2l1, Fgfr1, and Mtcp1) and included functions and components relating to GTPase-mediated signal transduction (Grb2, Rab7, Rab12, Rab35, and Ralbp1), chromatin (H2faz, Scmh1, and 5430405G24Rik), ribosomes (Rpl8, Rpl13, and Rps16), and mitochondria (Atpif1, C1qbp, Cndp2, Mtcp1, Pdha1, and Phb).

Localization (response) of UVB

1) Confidence 0.05 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.05 Pain Relevance 0

General Comments

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