INT201605

Context Info Confidence 0.04 First Reported 2007 Last Reported 2007 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 4 Disease Relevance 1.25 Pain Relevance 0.38

Anatomy Link Frequency skin 2 reticulum 1 Uvbi1 (Mus musculus)

Pain Link Frequency Relevance Heat melanocortin 1 receptor 132 73.44

Disease Link Frequency Relevance Heat Repression 24 100.00 Stress 44 96.68 Dna Damage 4 92.12 Burns 20 88.68 Skin Cancer 196 75.00 Cancer 36 71.24 Metastasis 44 58.32 Death 8 48.36 Blister 4 41.60 Colon Cancer 4 8.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Indeed, the cDNA whose UVB-induced repression exhibited the most significant p-value in our data set was Polr2e, one of a dozen subunits of RNA polymerase II.

Regulation (value) of UVB associated with repression

1) Confidence 0.04 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.29 Pain Relevance 0

To better understand how the skin responds to UV radiation as an integrated tissue, we have examined the whole genome transcriptional response to UVB radiation in neonatal mouse skin using a combination of genomic, genetic, and bioinformatic approaches.

Spec (examined) Regulation (response) of UVB in skin

2) Confidence 0.03 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.12 Pain Relevance 0.18

From the cDNAs shown to be UVB responsive in the basal epidermis (Figure 1 and Table S1), we identified a nonredundant set of 1,201 UniGene IDs.

Regulation (responsive) of UVB in epidermis

3) Confidence 0.02 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.17 Pain Relevance 0

The Kit-dependent UVB response was characterized largely by an enrichment of oxidative and endoplasmic reticulum stress genes, highlighting a distinctive role for pigmented melanocytes in mediating antioxidant defenses against genotoxic stresses within the basal epidermal environment.

Regulation (response) of UVB in reticulum associated with stress and dna damage

4) Confidence 0.02 Published 2007 Journal PLoS Genetics Section Abstract Doc Link PMC1774588 Disease Relevance 0.67 Pain Relevance 0.21

General Comments

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