INT201605

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.25
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
skin 2
reticulum 1
Uvbi1 (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 132 73.44 Quite High
Disease Link Frequency Relevance Heat
Repression 24 100.00 Very High Very High Very High
Stress 44 96.68 Very High Very High Very High
Dna Damage 4 92.12 High High
Burns 20 88.68 High High
Skin Cancer 196 75.00 Quite High
Cancer 36 71.24 Quite High
Metastasis 44 58.32 Quite High
Death 8 48.36 Quite Low
Blister 4 41.60 Quite Low
Colon Cancer 4 8.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, the cDNA whose UVB-induced repression exhibited the most significant p-value in our data set was Polr2e, one of a dozen subunits of RNA polymerase II.
Regulation (value) of UVB associated with repression
1) Confidence 0.04 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.29 Pain Relevance 0
To better understand how the skin responds to UV radiation as an integrated tissue, we have examined the whole genome transcriptional response to UVB radiation in neonatal mouse skin using a combination of genomic, genetic, and bioinformatic approaches.
Spec (examined) Regulation (response) of UVB in skin
2) Confidence 0.03 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.12 Pain Relevance 0.18
From the cDNAs shown to be UVB responsive in the basal epidermis (Figure 1 and Table S1), we identified a nonredundant set of 1,201 UniGene IDs.
Regulation (responsive) of UVB in epidermis
3) Confidence 0.02 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.17 Pain Relevance 0
The Kit-dependent UVB response was characterized largely by an enrichment of oxidative and endoplasmic reticulum stress genes, highlighting a distinctive role for pigmented melanocytes in mediating antioxidant defenses against genotoxic stresses within the basal epidermal environment.
Regulation (response) of UVB in reticulum associated with stress and dna damage
4) Confidence 0.02 Published 2007 Journal PLoS Genetics Section Abstract Doc Link PMC1774588 Disease Relevance 0.67 Pain Relevance 0.21

General Comments

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