INT201610

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Context Info
Confidence 0.31
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.75
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Mc1r, Braf) plasma membrane (Mc1r, Braf) pigmentation (Mc1r)
nucleus (Braf) kinase activity (Braf) cytoplasm (Braf)
Mc1r (Mus musculus)
Braf (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 33 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Melanoma 2 99.12 Very High Very High Very High
Skin Cancer 49 93.76 High High
Cancer 9 86.60 High High
Death 2 55.92 Quite High
Apoptosis 6 44.96 Quite Low
Repression 6 11.20 Low Low
Metastasis 11 5.00 Very Low Very Low Very Low
Stress 11 5.00 Very Low Very Low Very Low
Burns 5 5.00 Very Low Very Low Very Low
Hypersensitivity 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because the association between MC1R variation and BRAF was most apparent in melanomas without evidence of chronic sun damage, Landi et al. hypothesized that UV radiation acted indirectly to promote BRAF-mutant melanoma, which is also consistent with our findings.
MC1R Binding (association) of BRAF associated with melanocortin 1 receptor, melanoma and skin cancer
1) Confidence 0.31 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.75 Pain Relevance 0.42

General Comments

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