INT201614

Context Info Confidence 0.04 First Reported 2007 Last Reported 2007 Negated 0 Speculated 2 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.42 Pain Relevance 0.98

pigmentation (Mc1r) signal transduction (Mc1r) plasma membrane (Mc1r) signal transducer activity (Mc1r)

Anatomy Link Frequency melanocytes 1 keratinocytes 1 Mc1r (Mus musculus) Uvbi1 (Mus musculus)

Pain Link Frequency Relevance Heat melanocortin 1 receptor 66 85.84

Disease Link Frequency Relevance Heat Skin Cancer 98 93.16 Melanoma 4 87.84 Death 4 85.20 Apoptosis 12 74.24 Cancer 18 71.48 Metastasis 22 5.00 Stress 22 5.00 Repression 12 5.00 Burns 10 5.00 Hypersensitivity 10 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The nature of our experimental system—an integrated tissue collected from whole animals—makes it difficult to assess whether Mc1r signaling might affect UVB-induced cell cycle arrest in keratinocytes, melanocytes, or both.

Mc1r Spec (might) Regulation (affect) of UVB in melanocytes

1) Confidence 0.04 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.71 Pain Relevance 0.49

The nature of our experimental system—an integrated tissue collected from whole animals—makes it difficult to assess whether Mc1r signaling might affect UVB-induced cell cycle arrest in keratinocytes, melanocytes, or both.

Mc1r Spec (might) Regulation (affect) of UVB in keratinocytes

2) Confidence 0.01 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.71 Pain Relevance 0.49

General Comments

This test has worked.