INT201628

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.68
First Reported 2006
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 12
Total Number 15
Disease Relevance 13.86
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Bad) cell proliferation (Bad) cytosol (Bad)
mitochondrion (Bad) cytoplasm (Bad)
Anatomy Link Frequency
brain 2
epithelium 2
Bad (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 17 94.40 High High
cytokine 8 90.72 High High
withdrawal 14 86.84 High High
imagery 66 79.36 Quite High
addiction 13 75.20 Quite High
antagonist 40 68.12 Quite High
isoflurane 13 61.28 Quite High
anesthesia 13 59.88 Quite High
agonist 14 40.16 Quite Low
long-term potentiation 6 26.96 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 488 100.00 Very High Very High Very High
Prostate Cancer 442 99.84 Very High Very High Very High
Cancer 327 99.84 Very High Very High Very High
Encephalitis 4 94.40 High High
Toxicity 17 91.52 High High
Prion Diseases 35 91.08 High High
Shock 1 88.96 High High
Breast Cancer 13 86.80 High High
Death 83 82.28 Quite High
Necrosis 3 80.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This connection between BAD expression and proliferation provides a possible explanation for an increase in expression of phosphorylated BAD protein in prostate tumors.
Spec (possible) Positive_regulation (increase) of Gene_expression (expression) of BAD protein associated with prostate cancer
1) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 0.76 Pain Relevance 0
Analysis of the effect of BAD on prostate cancer xenografts has shown that increased BAD expression enhances tumor growth, while knockdown of BAD expression by shRNA inhibits tumor growth.
Positive_regulation (increased) of Gene_expression (expression) of BAD associated with cancer and prostate cancer
2) Confidence 0.46 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2704953 Disease Relevance 1.40 Pain Relevance 0
Regardless of the exact mechanism that permits BAD to stimulate tumor growth, this capacity may provide selective pressure to increase BAD expression in tumors.
Positive_regulation (increase) of Gene_expression (expression) of BAD associated with cancer
3) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 0.63 Pain Relevance 0
Here we report that increased BAD expression stimulates proliferation of prostate cancer cells in tissue culture and prostate tumor growth in vivo.
Positive_regulation (increased) of Gene_expression (expression) of BAD associated with prostate cancer
4) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 1.30 Pain Relevance 0.10
A recent study has shown that BAD expression is elevated in prostatic carcinomas compared to low expression in normal prostatic epithelium [13].
Positive_regulation (elevated) of Gene_expression (expression) of BAD in epithelium associated with prostate cancer
5) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 1.35 Pain Relevance 0.08
To address the possible role of increased BAD expression, we examined proliferation of prostate cancer cells that overexpress BAD.
Spec (possible) Positive_regulation (increased) of Gene_expression (expression) of BAD associated with prostate cancer
6) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 0.38 Pain Relevance 0.14
Tissue culture experiments demonstrated that increased BAD expression stimulates proliferation of prostate cancer cells.
Positive_regulation (increased) of Gene_expression (expression) of BAD associated with prostate cancer
7) Confidence 0.46 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2704953 Disease Relevance 1.42 Pain Relevance 0
To determine whether increased expression levels of BAD stimulate prostate tumor growth in vivo, we compared growth of C4-2Luc and C4-2LucBAD cells implanted in immunocompromised mice.
Spec (whether) Positive_regulation (increased) of Gene_expression (expression) of BAD associated with prostate cancer
8) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 0.83 Pain Relevance 0.04
These results suggest that increased expression of BAD provides a proliferative advantage to prostate tumors, while BAD dephosphorylation increases sensitivity of prostate cancer cells to apoptosis.
Positive_regulation (increased) of Gene_expression (expression) of BAD associated with prostate cancer and apoptosis
9) Confidence 0.40 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2704953 Disease Relevance 1.43 Pain Relevance 0
To address the possible role of increased BAD expression, we examined proliferation of prostate cancer cells that overexpress BAD.
Positive_regulation (overexpress) of Gene_expression (overexpress) of BAD associated with prostate cancer
10) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 0.43 Pain Relevance 0.06
Increased levels of BAD in prostate carcinomas have also been reported.
Positive_regulation (Increased) of Gene_expression (levels) of BAD associated with prostate cancer
11) Confidence 0.40 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2704953 Disease Relevance 1.01 Pain Relevance 0
Reports on increased expression of BAD in prostate cancer led us to suggest that prostate cancer cells may benefit from maintaining BAD expression.
Positive_regulation (increased) of Gene_expression (expression) of BAD associated with prostate cancer
12) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 0.43 Pain Relevance 0.21
Activation of protein kinases that phosphorylate BAD creates a permissive condition to increased expression of BAD.
Positive_regulation (increased) of Gene_expression (expression) of BAD
13) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 0.56 Pain Relevance 0
Treatment with FK506 led to a significant increase of pCREB and pBAD levels in the brain, which paralleled the decrease of CaN activity.
Positive_regulation (increase) of Gene_expression (levels) of pBAD in brain
14) Confidence 0.17 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2951383 Disease Relevance 0.59 Pain Relevance 0.05
The Bcl-2 family includes pro-apoptotic (Bax and Bad) and anti-apoptotic (Bcl-2 and Bcl-XL) proteins, whose expression and activity is regulated through different signaling pathways including trophic factors deprivation, A?
Positive_regulation (apoptotic) of Gene_expression (expression) of Bad associated with apoptosis
15) Confidence 0.04 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 1.34 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox