INT201635

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Context Info
Confidence 0.40
First Reported 2006
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.15
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk1) plasma membrane (Ntrk1) kinase activity (Ntrk1)
cytoplasm (Ntrk1)
Ntrk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 14 97.44 Very High Very High Very High
dorsal root ganglion 55 96.80 Very High Very High Very High
nociceptor 20 83.56 Quite High
substance P 8 82.20 Quite High
Neuropeptide 11 80.40 Quite High
long-term potentiation 5 76.20 Quite High
Nerve growth factor 29 70.48 Quite High
Freund adjuvant 1 63.04 Quite High
Kinase C 5 62.24 Quite High
Inflammation 11 61.60 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 124 96.80 Very High Very High Very High
Repression 3 91.76 High High
Aging 5 85.52 High High
Targeted Disruption 34 82.16 Quite High
Disease 128 81.52 Quite High
Cognitive Disorder 16 81.28 Quite High
Apoptosis 143 74.72 Quite High
Nociception 13 69.76 Quite High
INFLAMMATION 15 61.60 Quite High
Hematological Disease 2 46.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One possible explanation is that the minimal enhancer of trkA, which Runx1 regulates [35], may not be required for the de novo induction of trkA expression [36].
Neg (not) Positive_regulation (required) of Positive_regulation (enhancer) of trkA
1) Confidence 0.40 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.65 Pain Relevance 0.29
Although these cells are trkB-positive, an increasing population of trkA-positive cells expresses ret during the third embryonic week.
Positive_regulation (increasing) of Positive_regulation (population) of trkA
2) Confidence 0.21 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.12 Pain Relevance 0.40
In PC12 cells, APP transcription and secretion have been found to be regulated by NGF and its receptors TrkA and p75: TrkA activation increases APP processing and secretion, while p75 signaling increases APP transcription [117].
Positive_regulation (increases) of Positive_regulation (activation) of TrkA
3) Confidence 0.06 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.38 Pain Relevance 0.15

General Comments

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