INT201636

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Context Info
Confidence 0.18
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.79
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Cdk5r1) plasma membrane (Cdk5r1) nucleus (Cdk5r1)
embryo development (Cdk5r1) cell cycle (Cdk5r1) kinase activity (Cdk5r1)
Anatomy Link Frequency
cleavage 4
Cdk5r1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 72 93.32 High High
Inflammation 27 71.12 Quite High
Glutamate receptor 5 54.24 Quite High
Glutamate 5 53.00 Quite High
agonist 3 11.96 Low Low
Central nervous system 8 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Hippocampus 8 5.00 Very Low Very Low Very Low
Eae 6 5.00 Very Low Very Low Very Low
long-term potentiation 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 28 99.00 Very High Very High Very High
Cv General 4 Under Development 15 93.32 High High
Death 129 90.88 High High
Apoptosis 152 85.68 High High
Stroke 84 83.44 Quite High
Disease 167 80.96 Quite High
Brain Hemorrhage 15 78.80 Quite High
Alzheimer's Dementia 8 77.24 Quite High
Neurodegenerative Disease 40 77.04 Quite High
INFLAMMATION 32 71.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Deregulation of CDK5 under pathological conditions is induced by calpain- mediated cleavage of p35 into a shorter form p25.
Protein_catabolism (cleavage) of p35 in cleavage
1) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920814 Disease Relevance 0.94 Pain Relevance 0.20
These data suggested that pMCAo induced cleavage of p35 to p25, with subsequent activation of CDK5/p25 activity.
Protein_catabolism (cleavage) of p35 in cleavage
2) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920814 Disease Relevance 0.16 Pain Relevance 0.04
Deregulation of CDK5 under pathological conditions is induced by calpain- mediated cleavage of p35 into a shorter form p25.
Protein_catabolism (cleavage) of p25 in cleavage
3) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920814 Disease Relevance 0.94 Pain Relevance 0.20
42, p35 is cleaved by calpain to form p25.
Protein_catabolism (cleaved) of p35
4) Confidence 0.06 Published 2009 Journal Microb Cell Fact Section Body Doc Link PMC2674406 Disease Relevance 0.51 Pain Relevance 0
due to downregulation of PI3K/Akt, as well as by activation of the p25-cdk5 complex following Ca2+-dependent activation of calpains and cleavage of p35, and both pathways can become synergistically activated upon trophic factors deprivation and ROS accumulation, suggesting that cells use more than one route to respond to stimuli.
Protein_catabolism (cleavage) of p35 in cleavage
5) Confidence 0.04 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.24 Pain Relevance 0

General Comments

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