INT201638

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Context Info
Confidence 0.58
First Reported 2005
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.38
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Cdk4) cytosol (Cdk4) signal transduction (Cdk4)
nucleolus (Cdk4) nucleus (Cdk4) cell cycle (Cdk4)
Anatomy Link Frequency
telomere 1
Cdk4 (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 1 62.76 Quite High
Potency 4 62.00 Quite High
fibrosis 1 61.12 Quite High
Chronic pancreatitis 1 60.44 Quite High
Inflammation 20 57.68 Quite High
cytokine 16 56.64 Quite High
chemokine 5 35.44 Quite Low
Inflammatory mediators 4 27.76 Quite Low
cINOD 10 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinoblastoma 2 98.92 Very High Very High Very High
Disease 136 94.08 High High
Aging 6 92.96 High High
Stress 37 91.52 High High
Heart Rate Under Development 3 89.68 High High
Cancer 78 89.60 High High
Pancreatic Cancer 27 86.00 High High
Apoptosis 175 81.60 Quite High
Carcinoma 1 78.72 Quite High
Infection 76 77.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B–mediated upregulation of c-Myc, cyclins, and CDK4 [7,10,11].
Positive_regulation (upregulation) of CDK4
1) Confidence 0.58 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.63 Pain Relevance 0.06
and CDK4 were not increased [71].
Neg (not) Positive_regulation (increased) of CDK4
2) Confidence 0.20 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.38 Pain Relevance 0
The Oct4-overexpressed ATSC cells showed prominent effects on upregulation of a variety of proliferation-associated genes, including RUNX3, CDK2 and CDK4, and telomere reverse transcriptase (TERT; Fig. 1D).
Positive_regulation (upregulation) of CDK4 in telomere
3) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0.08 Pain Relevance 0.03
induces upregulation of cdk4/6, phosphorylation of the retinoblastoma protein pRb/107, release of Rb from the transcription factor complex E2F-DP and activation of E2F-mediated trascription of genes required for S phase transition, but these events occur in a p53-independent manner [214].
Positive_regulation (upregulation) of cdk4 associated with retinoblastoma
4) Confidence 0.06 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 1.09 Pain Relevance 0.06
When p16 genes are mutated, cyclin-dependent kinase 4 activation is increased and hyperphosphorylation of Rb protein occurs, leading to accentuated progression of the cell cycle from G1 to S and to cell proliferation.
Positive_regulation (activation) of cyclin-dependent kinase 4
5) Confidence 0.02 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2815837 Disease Relevance 1.19 Pain Relevance 0.09

General Comments

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