INT201641

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Context Info
Confidence 0.16
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.36
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Apaf1) Golgi apparatus (Apaf1) nucleus (Apaf1)
intracellular (Apaf1) cytoplasm (Apaf1)
Apaf1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 32 65.32 Quite High
Inflammation 27 5.00 Very Low Very Low Very Low
Hippocampus 7 5.00 Very Low Very Low Very Low
Eae 6 5.00 Very Low Very Low Very Low
long-term potentiation 5 5.00 Very Low Very Low Very Low
Kinase C 5 5.00 Very Low Very Low Very Low
Neurotransmitter 5 5.00 Very Low Very Low Very Low
corticosteroid 5 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 236 100.00 Very High Very High Very High
Parkinson's Disease 9 90.36 High High
Death 84 83.16 Quite High
Disease 148 82.44 Quite High
Carcinoma 20 77.20 Quite High
Stress 34 73.92 Quite High
Cancer 91 66.48 Quite High
Toxicity 16 64.88 Quite High
Metastasis 17 50.00 Quite Low
Shock 1 45.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The released cytochrome c binds to the apoptosis protease-activating factor-1 (Apaf-1), and this complex activates caspase-9.
Apaf-1 Binding (binds) of associated with apoptosis
1) Confidence 0.16 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978204 Disease Relevance 0.98 Pain Relevance 0
For instance, caspase-8 can be activated following recruitment and clustering at multicomponent apoptosis-signaling complexes, resulting from ligation of cell surface molecules of the TNF receptor family, presumably by auto-processing of the zymogens according to the induced-proximity model.116 Caspase-9 is activated by recruitment to Apaf-1 in the presence of ATP following release of cytochrome c from mitochondria.117
Apaf-1 Binding (recruitment) of associated with apoptosis
2) Confidence 0.07 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 0.51 Pain Relevance 0
Oligomerization of APAF-1 promotes the allosteric activation of caspase-9.
APAF-1 Binding (Oligomerization) of
3) Confidence 0.03 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.88 Pain Relevance 0.03

General Comments

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