INT201646

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Context Info
Confidence 0.58
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 7.14
Pain Relevance 2.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
hippocampus 12
vein 2
cortex 1
frontal cortex 1
Bdnf (Mus musculus)
Pain Link Frequency Relevance Heat
depression 411 99.96 Very High Very High Very High
Hippocampus 265 99.84 Very High Very High Very High
antidepressant 322 95.40 Very High Very High Very High
long-term potentiation 23 95.20 Very High Very High Very High
monoamine 11 94.80 High High
midbrain 15 91.96 High High
B1 receptor 34 89.28 High High
antagonist 33 88.32 High High
dexamethasone 10 83.92 Quite High
opiate 5 69.88 Quite High
Disease Link Frequency Relevance Heat
Depression 530 99.96 Very High Very High Very High
Stress 190 99.48 Very High Very High Very High
Suicidal Behaviour 615 99.38 Very High Very High Very High
Disease 257 99.14 Very High Very High Very High
Cognitive Disorder 74 98.64 Very High Very High Very High
Urological Neuroanatomy 86 95.46 Very High Very High Very High
Repression 10 89.80 High High
Neurodegenerative Disease 87 88.08 High High
Infection 5 77.76 Quite High
Amyloid Plaque 10 76.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The very first study that examined the role of stress was from Smith and colleagues,83 who demonstrated that immobilization stress used for 1 or 7 days (for 2 hours per day) significantly decreased BDNF mRNA expression in the hippocampus.
Negative_regulation (decreased) of Transcription (expression) of BDNF in hippocampus associated with stress and hippocampus
1) Confidence 0.58 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 1.02 Pain Relevance 0.28
We observed that corticosterone selectively decreased the expression of transcripts II and IV, but not transcripts I or III, in both the frontal cortex and hippocampus.92 Two other recent studies suggest that immobilization stress decreases total BDNF expression, along with a specific decrease in exon IV in the hippocampus96 and hypothalamus.97 These studies suggest that the decrease of BDNF mRNA expression by glucocorticoids may be due to a decrease in expression of the specific BDNF transcripts that contain exons II and IV.


Negative_regulation (decrease) of Transcription (expression) of BDNF in hippocampus associated with stress, urological neuroanatomy and hippocampus
2) Confidence 0.58 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.59 Pain Relevance 0.29
Recently, Fuchikami et al179 reported that single immobilization stress (a model for depression) decreased the levels of BDNF mRNA, which was associated with decreased expression of exons I and IV.
Negative_regulation (decreased) of Transcription (levels) of BDNF associated with stress and depression
3) Confidence 0.58 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.67 Pain Relevance 0.14
Our depression model caused a sustained reduction in BDNF mRNA expression in hippocampus (up to 24 h).
Negative_regulation (reduction) of Transcription (expression) of BDNF in hippocampus associated with depression and hippocampus
4) Confidence 0.40 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3022820 Disease Relevance 0.70 Pain Relevance 0.85
In addition to adult suicide subjects, we recently examined the expression of BDNF in postmortem brain samples obtained from teenaged suicide subjects.184 Protein and mRNA expression of BDNF was determined in samples from the PFC, Brodmann’s area 9, and hippocampus obtained from 22 teenaged suicide victims and 22 matched nonpsychiatric healthy control subjects.
Spec (determined) Negative_regulation (determined) of Transcription (expression) of BDNF in hippocampus associated with suicidal behaviour and hippocampus
5) Confidence 0.37 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.95 Pain Relevance 0.30
In a similar vein, BDNF and zif268 mRNA expression were reported in the entorhinal and prefrontal cortices after object sampling, while in this experiment reactivation 9 days after training induced zif268 in entorhinal and somatosensory cortices and upon reactivation 21 days after training, BDNF and not zif268 was expressed in hippocampus and entorhinal and somatosensory cortices (Romero-Granados et al., 2010).
Negative_regulation (reported) of Transcription (expression) of BDNF in vein associated with hippocampus
6) Confidence 0.22 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2992451 Disease Relevance 0.05 Pain Relevance 0.07
We observed that corticosterone selectively decreased the expression of transcripts II and IV, but not transcripts I or III, in both the frontal cortex and hippocampus.92 Two other recent studies suggest that immobilization stress decreases total BDNF expression, along with a specific decrease in exon IV in the hippocampus96 and hypothalamus.97 These studies suggest that the decrease of BDNF mRNA expression by glucocorticoids may be due to a decrease in expression of the specific BDNF transcripts that contain exons II and IV.


Negative_regulation (decrease) of in frontal cortex Transcription (expression) of BDNF in hippocampus associated with stress, urological neuroanatomy and hippocampus
7) Confidence 0.20 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.59 Pain Relevance 0.29
The potential role of BDNF in AD is supported by several studies showing a reduction of BDNF mRNA and protein levels in the cortex and hippocampus of MCI and severe AD patients [58,88].
Negative_regulation (reduction) of Transcription (levels) of BDNF in hippocampus associated with cognitive disorder, hippocampus and disease
8) Confidence 0.10 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 1.29 Pain Relevance 0.19
The potential role of BDNF in AD is supported by several studies showing a reduction of BDNF mRNA and protein levels in the cortex and hippocampus of MCI and severe AD patients [58,88].
Negative_regulation (reduction) of in cortex Transcription (levels) of BDNF in hippocampus associated with cognitive disorder, hippocampus and disease
9) Confidence 0.03 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 1.29 Pain Relevance 0.19

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