INT201653

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Context Info
Confidence 0.75
First Reported 2006
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 6
Total Number 35
Disease Relevance 6.29
Pain Relevance 4.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Sort1) endosome (Sort1) transport (Sort1)
Golgi apparatus (Sort1) endoplasmic reticulum (Sort1) enzyme binding (Sort1)
Anatomy Link Frequency
plasma 4
brain 4
neurons 3
pyramidal cells 2
cleavage 2
Sort1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 125 99.22 Very High Very High Very High
Raphe 120 98.88 Very High Very High Very High
antidepressant 1980 98.32 Very High Very High Very High
Nucleus accumbens 60 98.32 Very High Very High Very High
depression 1020 97.64 Very High Very High Very High
Hippocampus 305 97.56 Very High Very High Very High
amygdala 65 97.04 Very High Very High Very High
antagonist 125 88.44 High High
potassium channel 180 85.32 High High
sSRI 270 69.72 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 665 99.32 Very High Very High Very High
Depression 1020 97.64 Very High Very High Very High
Death 340 96.52 Very High Very High Very High
Injury 95 75.52 Quite High
Neurodegenerative Disease 660 71.84 Quite High
Stress 370 61.64 Quite High
Disease 725 55.44 Quite High
Mental Disorders 30 52.20 Quite High
Body Weight 60 48.36 Quite Low
Cognitive Disorder 80 40.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
COS-7 cells were chosen because they weakly express the NTSR3/Sortilin receptor (unpublished data).
Gene_expression (express) of NTSR3
1) Confidence 0.75 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854129 Disease Relevance 0 Pain Relevance 0
We first characterized the affinity of spadin on C13NJ, a microglial cell line expressing only NTSR3/Sortilin as a receptor for NT, and devoid of TREK-1 (unpublished data).
Gene_expression (expressing) of NTSR3 in microglial cell
2) Confidence 0.75 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854129 Disease Relevance 0.07 Pain Relevance 0
We first characterized the affinity of spadin on C13NJ, a microglial cell line expressing only NTSR3/Sortilin as a receptor for NT, and devoid of TREK-1 (unpublished data).
Gene_expression (expressing) of Sortilin in microglial cell
3) Confidence 0.68 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854129 Disease Relevance 0.08 Pain Relevance 0
COS-7 cells were chosen because they weakly express the NTSR3/Sortilin receptor (unpublished data).
Gene_expression (express) of Sortilin
4) Confidence 0.68 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854129 Disease Relevance 0 Pain Relevance 0.03
Characterization of the interaction between NTSR3/Sortilin, spadin, and TREK-1
Gene_expression (/) of NTSR3
5) Confidence 0.65 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854129 Disease Relevance 0 Pain Relevance 0.07
In the rat brain, NTSR3/Sortilin as well as TREK-1 are highly expressed in cerebral structures involved in the pathophysiology of depression [13], such as prefrontal and cingulate cortice, amygdala, hippocampus, nucleus accumbens, dorsal raphe, and hypothalamus [7],[8].
Gene_expression (expressed) of NTSR3 in brain associated with nucleus accumbens, depression, hippocampus, raphe and amygdala
6) Confidence 0.65 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854129 Disease Relevance 0.19 Pain Relevance 0.24
NTSR3/Sortilin is synthesized as a proform (prosortilin) that, in late Golgi compartments, is converted to the functional ligand-binding receptor by cleavage and release of a 44 residue N-terminal propeptide (Gln1-Arg44, propeptide) by furin [14].
Gene_expression (synthesized) of NTSR3 in cleavage
7) Confidence 0.65 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854129 Disease Relevance 0.18 Pain Relevance 0.24
This interaction between TREK-1 and NTSR3/Sortilin led us to examine whether NT and/or the partial NTSR3/Sortilin propeptide (i.e. spadin) were able to act on TREK-1 channel activity.
Gene_expression (/) of NTSR3
8) Confidence 0.65 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854129 Disease Relevance 0.06 Pain Relevance 0.03
The expression of TREK-1 within the plasma membranes, measured either by preparing purified plasma membranes or by using cell surface biotinylation, was enhanced (by a factor 3 and 6, respectively) when COS-7 cells were cotransfected with NTSR3/Sortilin (Figure 1C), confirming the interaction between the two proteins, at least during the channel sorting.
Gene_expression (cotransfected) of NTSR3 in plasma
9) Confidence 0.65 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854129 Disease Relevance 0.06 Pain Relevance 0.09
This interaction between TREK-1 and NTSR3/Sortilin led us to examine whether NT and/or the partial NTSR3/Sortilin propeptide (i.e. spadin) were able to act on TREK-1 channel activity.
Spec (partial) Gene_expression (partial) of NTSR3
10) Confidence 0.65 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854129 Disease Relevance 0.06 Pain Relevance 0.03
This interaction between TREK-1 and NTSR3/Sortilin led us to examine whether NT and/or the partial NTSR3/Sortilin propeptide (i.e. spadin) were able to act on TREK-1 channel activity.
Gene_expression (/) of NTSR3
11) Confidence 0.65 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854129 Disease Relevance 0.11 Pain Relevance 0.05
This interaction between TREK-1 and NTSR3/Sortilin led us to examine whether NT and/or the partial NTSR3/Sortilin propeptide (i.e. spadin) were able to act on TREK-1 channel activity.
Gene_expression (/) of Sortilin
12) Confidence 0.59 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854129 Disease Relevance 0.11 Pain Relevance 0.05
Here, we validate in mice the antidepressant effects of spadin, a secreted peptide derived from the propeptide generated by the maturation of the neurotensin receptor 3 (NTSR3/Sortilin) and acting through TREK-1 inhibition.
Gene_expression (maturation) of neurotensin receptor 3 associated with antidepressant
13) Confidence 0.59 Published 2010 Journal PLoS Biology Section Abstract Doc Link PMC2854129 Disease Relevance 0.26 Pain Relevance 0.50
Characterization of the interaction between NTSR3/Sortilin, spadin, and TREK-1
Gene_expression (/) of Sortilin
14) Confidence 0.59 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854129 Disease Relevance 0 Pain Relevance 0.07
This interaction between TREK-1 and NTSR3/Sortilin led us to examine whether NT and/or the partial NTSR3/Sortilin propeptide (i.e. spadin) were able to act on TREK-1 channel activity.
Spec (whether) Gene_expression (propeptide) of Sortilin
15) Confidence 0.59 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854129 Disease Relevance 0.06 Pain Relevance 0.03
The expression of TREK-1 within the plasma membranes, measured either by preparing purified plasma membranes or by using cell surface biotinylation, was enhanced (by a factor 3 and 6, respectively) when COS-7 cells were cotransfected with NTSR3/Sortilin (Figure 1C), confirming the interaction between the two proteins, at least during the channel sorting.
Gene_expression (cotransfected) of Sortilin in plasma
16) Confidence 0.59 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854129 Disease Relevance 0.06 Pain Relevance 0.09
Here, we validate in mice the antidepressant effects of spadin, a secreted peptide derived from the propeptide generated by the maturation of the neurotensin receptor 3 (NTSR3/Sortilin) and acting through TREK-1 inhibition.
Gene_expression (maturation) of Sortilin associated with antidepressant
17) Confidence 0.59 Published 2010 Journal PLoS Biology Section Abstract Doc Link PMC2854129 Disease Relevance 0.26 Pain Relevance 0.50
This interaction between TREK-1 and NTSR3/Sortilin led us to examine whether NT and/or the partial NTSR3/Sortilin propeptide (i.e. spadin) were able to act on TREK-1 channel activity.
Gene_expression (/) of Sortilin
18) Confidence 0.59 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854129 Disease Relevance 0.06 Pain Relevance 0.03
In the rat brain, NTSR3/Sortilin as well as TREK-1 are highly expressed in cerebral structures involved in the pathophysiology of depression [13], such as prefrontal and cingulate cortice, amygdala, hippocampus, nucleus accumbens, dorsal raphe, and hypothalamus [7],[8].
Gene_expression (expressed) of Sortilin in brain associated with nucleus accumbens, depression, hippocampus, raphe and amygdala
19) Confidence 0.59 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854129 Disease Relevance 0.19 Pain Relevance 0.24
This interaction between TREK-1 and NTSR3/Sortilin led us to examine whether NT and/or the partial NTSR3/Sortilin propeptide (i.e. spadin) were able to act on TREK-1 channel activity.
Spec (partial) Gene_expression (partial) of Sortilin
20) Confidence 0.59 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854129 Disease Relevance 0.06 Pain Relevance 0.03

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