INT201654

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Context Info
Confidence 0.08
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Cdk4) cytosol (Cdk4) signal transduction (Cdk4)
nucleolus (Cdk4) nucleus (Cdk4) cell cycle (Cdk4)
Anatomy Link Frequency
nucleus 2
Cdk4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 18 5.00 Very Low Very Low Very Low
cytokine 16 5.00 Very Low Very Low Very Low
Hippocampus 14 5.00 Very Low Very Low Very Low
Eae 12 5.00 Very Low Very Low Very Low
long-term potentiation 10 5.00 Very Low Very Low Very Low
Kinase C 10 5.00 Very Low Very Low Very Low
Neurotransmitter 10 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
Neuropeptide 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 266 50.00 Quite Low
Disease 254 50.00 Quite Low
Neurodegenerative Disease 72 21.44 Low Low
Sprains And Strains 2 13.40 Low Low
Death 112 5.00 Very Low Very Low Very Low
Stress 64 5.00 Very Low Very Low Very Low
Cognitive Disorder 32 5.00 Very Low Very Low Very Low
Toxicity 30 5.00 Very Low Very Low Very Low
INFLAMMATION 26 5.00 Very Low Very Low Very Low
Parkinson's Disease 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also p27Kip1, together with p21Cip1, has been shown to promote nuclear import of cognate cyclin D1/Cdk4, therefore the import of cyclins, that do not have obvious nuclear import signals, like cyclin D in mammals and Clb5 and Clb6 in yeast, appear to be imported into the nucleus piggy-backed on cargos (the complex cyclin/Cdk/Cki) that contains a protein (the Cki) with a NLS [23,24].
Localization (import) of Cdk4 in nucleus
1) Confidence 0.08 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0 Pain Relevance 0
Also p27Kip1, together with p21Cip1, has been shown to promote nuclear import of cognate cyclin D1/Cdk4, therefore the import of cyclins, that do not have obvious nuclear import signals, like cyclin D in mammals and Clb5 and Clb6 in yeast, appear to be imported into the nucleus piggy-backed on cargos (the complex cyclin/Cdk/Cki) that contains a protein (the Cki) with a NLS [23,24].
Localization (import) of Cdk4 in nucleus
2) Confidence 0.08 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0 Pain Relevance 0

General Comments

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