INT201656

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Context Info
Confidence 0.06
First Reported 2005
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.34
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Cdk4) cytosol (Cdk4) signal transduction (Cdk4)
nucleolus (Cdk4) nucleus (Cdk4) cell cycle (Cdk4)
Cdk4 (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 1 63.08 Quite High
fibrosis 1 61.12 Quite High
Chronic pancreatitis 1 60.44 Quite High
Inflammation 9 55.60 Quite High
cytokine 8 40.48 Quite Low
chemokine 1 35.44 Quite Low
Inflammatory mediators 2 27.76 Quite Low
Hippocampus 7 5.00 Very Low Very Low Very Low
Eae 6 5.00 Very Low Very Low Very Low
long-term potentiation 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinoblastoma 1 98.92 Very High Very High Very High
Disease 134 94.40 High High
Aging 5 93.28 High High
Stress 32 91.84 High High
Cancer 26 89.60 High High
Pancreatic Cancer 26 86.00 High High
Apoptosis 135 82.64 Quite High
Carcinoma 1 79.04 Quite High
Diabetes Mellitus 2 61.68 Quite High
Cystic Fibrosis 1 61.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
induces upregulation of cdk4/6, phosphorylation of the retinoblastoma protein pRb/107, release of Rb from the transcription factor complex E2F-DP and activation of E2F-mediated trascription of genes required for S phase transition, but these events occur in a p53-independent manner [214].
Positive_regulation (induces) of Positive_regulation (upregulation) of cdk4 associated with retinoblastoma
1) Confidence 0.06 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 1.10 Pain Relevance 0.06
When p16 genes are mutated, cyclin-dependent kinase 4 activation is increased and hyperphosphorylation of Rb protein occurs, leading to accentuated progression of the cell cycle from G1 to S and to cell proliferation.
Positive_regulation (increased) of Positive_regulation (activation) of cyclin-dependent kinase 4
2) Confidence 0.02 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2815837 Disease Relevance 1.25 Pain Relevance 0.09

General Comments

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