INT20166

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Context Info
Confidence 0.56
First Reported 1981
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 32
Total Number 35
Disease Relevance 10.64
Pain Relevance 10.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mtor) mitochondrion (Mtor) Golgi apparatus (Mtor)
endoplasmic reticulum (Mtor) nucleus (Mtor) kinase activity (Mtor)
Anatomy Link Frequency
spinal cord 2
neuronal 2
spinal 2
nerve 2
muscle 1
Mtor (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 14 100.00 Very High Very High Very High
Cholecystokinin 9 99.90 Very High Very High Very High
Somatostatin 8 99.80 Very High Very High Very High
Spinal cord 114 99.68 Very High Very High Very High
qutenza 272 99.56 Very High Very High Very High
Dorsal horn 68 99.36 Very High Very High Very High
Lasting pain 43 98.96 Very High Very High Very High
Intracerebroventricular 5 98.46 Very High Very High Very High
long-term potentiation 63 96.20 Very High Very High Very High
agonist 67 96.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 159 99.76 Very High Very High Very High
Neointima 66 99.50 Very High Very High Very High
Hyperplasia 24 99.18 Very High Very High Very High
Metastasis 16 99.14 Very High Very High Very High
Appetite Loss 18 99.04 Very High Very High Very High
Pain 113 98.96 Very High Very High Very High
Tuberous Sclerosis 2 98.88 Very High Very High Very High
Nervous System Injury 67 98.20 Very High Very High Very High
Renal Cancer 108 98.14 Very High Very High Very High
Hypersensitivity 77 97.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is widely accepted that rapamycin is a highly specific inhibitor of mTOR.
Negative_regulation (inhibitor) of mTOR
1) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0
After complete transection of the brachial plexus, partial depletion of FRAP was seen in the lower cervical and upper thoracic cord; the degree of FRAP disappearance was striking in segments C5, C6 and C7, and slight between segments C5 and C6.
Negative_regulation (depletion) of FRAP in upper
2) Confidence 0.55 Published 1986 Journal Acta Morphol Hung Section Abstract Doc Link 3037858 Disease Relevance 0.21 Pain Relevance 0.09
However, on the 7th day, with the exception of decrease of SP-LI and FRAP, the ENK-LI in dorsal horn was strengthened and the activity of FRAP in spinal ganglionic cells of B type disappeared.
Negative_regulation (decrease) of FRAP in spinal associated with dorsal horn
3) Confidence 0.54 Published 1990 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 2125862 Disease Relevance 0.45 Pain Relevance 1.81
Furthermore, we demonstrate that local treatment with rapamycin, an inhibitor of mTOR activity, both inhibits local protein synthesis and reduces the mechanical and thermal response of A- nociceptors.
Negative_regulation (inhibitor) of mTOR in nociceptors associated with nociceptor
4) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0.42 Pain Relevance 0.50
Using western blotting and immunohistochemistry, we found that intraplantar injections of rapamycin reduced phosphorylation of downstream targets of mTOR, therefore suggesting that mTOR activity was inhibited by rapamycin.
Negative_regulation (inhibited) of mTOR
5) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0.09 Pain Relevance 0.07
It is widely accepted that rapamycin is a highly specific inhibitor of mTOR.
Negative_regulation (inhibitor) of rapamycin
6) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0
Compared to cells treated with insulin alone, cells treated with rosiglitazone before insulin stimulus demonstrated significant inhibition of phosphorylated mTOR.


Negative_regulation (inhibition) of mTOR
7) Confidence 0.46 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.30 Pain Relevance 0
Rapamycin is a specific inhibitor of mTOR function that prevents p70S6K and 4E-BPs phosphorylation thus interfering with the initiation of translation [11] of a subset of mRNAs rather than general translation [12].
Negative_regulation (inhibitor) of mTOR
8) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.10
Rapamycin is a specific inhibitor of mTOR function that prevents p70S6K and 4E-BPs phosphorylation thus interfering with the initiation of translation [11] of a subset of mRNAs rather than general translation [12].
Negative_regulation (inhibitor) of Rapamycin
9) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.10
We investigated this by inhibiting the activity of mTOR with rapamycin at the spinal level, of rats that were subjected to the formalin test, using both behavioural and electrophysiological techniques.


Spec (investigated) Negative_regulation (inhibiting) of mTOR in spinal
10) Confidence 0.41 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2699332 Disease Relevance 0.42 Pain Relevance 0.52
To analyze the effect of mTOR and BDNF inhibition on GluR1 expression levels, IA-trained rats received bilateral intra-CA1 infusions of rapamycin (4.3 pg/side), anti-BDNF (0.5 ug/side) or saline 15 min before training and were killed by decapitation 15 min thereafter.
Spec (analyze) Negative_regulation (inhibition) of mTOR associated with decapitation
11) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0.15 Pain Relevance 0.08
Our previous studies showed that selective mTOR inhibitors such as rapamycin attenuate the neuronal plasticity and behavioral hypersensitivity associated with formalin by inhibiting mRNA translation since they exert the same effects as the global mRNA translation inhibitor anisomycin.1 Therefore, we are confident that CCI-779 acts specifically by inhibiting mTOR signaling pathways.
Negative_regulation (inhibitors) of mTOR in neuronal associated with hypersensitivity
12) Confidence 0.40 Published 2010 Journal The Journal of Pain Section Body Doc Link PMC3000494 Disease Relevance 0.67 Pain Relevance 0.19
We have recently shown that inhibiting mTOR signaling pathways prior to the formalin response attenuates acute behavioral hypersensitivity and neuronal hyperexcitability.1 In this present study, we inhibited spinal mTOR signaling pathways after full establishment of a persistent painlike state.
Negative_regulation (inhibiting) of mTOR in neuronal associated with hypersensitivity and hyperexcitability
13) Confidence 0.40 Published 2010 Journal The Journal of Pain Section Body Doc Link PMC3000494 Disease Relevance 0.93 Pain Relevance 0.14
Peripheral nerve section results in depletion of fluoride-resistant acid phosphatase (FRAP) from the nerve terminals in the dorsal horn of the spinal cord (Schoenen et al., '68) and this has been used in the past to map the termination field of individual nerves (Rustioni et al., '71; Devor and Claman, '80).
Negative_regulation (depletion) of FRAP in nerve associated with dorsal horn and spinal cord
14) Confidence 0.39 Published 1985 Journal J. Comp. Neurol. Section Abstract Doc Link 3880359 Disease Relevance 0 Pain Relevance 0.17
Changes in actin and myosin, were in turn, associated with a decrease in mTOR, a key regulator of protein translation [7], [9].
Negative_regulation (decrease) of mTOR
15) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.32 Pain Relevance 0.13
To confirm the specificity of the action of rapamycin on mTOR, we used ascomycin, an analog of FK506, which binds to FKBP12 but does not inhibit mTOR activity [43].
Negative_regulation (inhibit) of mTOR
16) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0.45 Pain Relevance 1.05
In the presence of rapamycin, the inhibition of mTOR signalling prevents the replenishment of the stores of these key proteins.
Negative_regulation (inhibition) of mTOR
17) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0.19 Pain Relevance 0.32
The mTOR inhibitor rapamycin blocks the phosphorylation of 4E-BP1/2, S6K and S6 in skin
Negative_regulation (blocks) of mTOR in skin
18) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0.06 Pain Relevance 0.34
Compared to cells treated with insulin alone, cells treated with rosiglitazone before insulin stimulus demonstrated a significant inhibitory effect on the proteins upstream, Akt, and downstream, P70S6K, of mTOR.
Negative_regulation (effect) of mTOR
19) Confidence 0.33 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.98 Pain Relevance 0.03
In conclusion, rosiglitazone inhibits neointimal hyperplasia after carotid balloon injury because it blocks the Akt-mTOR-P70S6 kinase pathway, resulting in inhibition of VSMC proliferation.
Negative_regulation (blocks) of mTOR associated with injury and hyperplasia
20) Confidence 0.33 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.89 Pain Relevance 0.03

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