INT201679

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.87
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IAPP) extracellular region (IAPP) cell-cell signaling (IAPP)
Anatomy Link Frequency
poly 1
IAPP (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 2 33.00 Quite Low
Neurotransmitter 5 32.00 Quite Low
Inflammation 9 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Hippocampus 7 5.00 Very Low Very Low Very Low
Eae 6 5.00 Very Low Very Low Very Low
long-term potentiation 5 5.00 Very Low Very Low Very Low
Kinase C 5 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 133 100.00 Very High Very High Very High
Parkinson's Disease 8 99.76 Very High Very High Very High
Neurodegenerative Disease 36 96.14 Very High Very High Very High
Disease 127 78.04 Quite High
Death 56 59.92 Quite High
Stress 32 5.00 Very Low Very Low Very Low
Cognitive Disorder 16 5.00 Very Low Very Low Very Low
Toxicity 15 5.00 Very Low Very Low Very Low
INFLAMMATION 13 5.00 Very Low Very Low Very Low
Injury 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The proposed basic blueprint for neuronal apoptosis shown in Figure 2 considers a trigger submodule (the DISC-system in the Bentele et al. paper), an actuator (the caspase submodule), a feed-forward module (mitochondrial dysfunction), a brake (IAP/Survivin/Cki) and the many degradative responses of apoptosis (degradation of proteins, poly(ADP-ribose)polymerase (PARP), DNA and so on).
Protein_catabolism (degradation) of IAP in poly associated with parkinson's disease, apoptosis and neurodegenerative disease
1) Confidence 0.01 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.87 Pain Relevance 0

General Comments

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